This page is designed to be a one-stop place for COVID-19 resources for researchers. It includes vivitide COVID-19 products, related items, related product categories, custom peptide synthesis and antibody services, product brochures, applicable viviBlogs, Product Spotlights, and aggregated news from multiple sources, which will all be updated frequently.
Both our Gardner, MA and Louisville, KY facilities are considered essential businesses, so we are working through this crisis to bring you the important products and information you need.
Image by Travis Schneider
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Related Catalog Product Categories
- ACE Inhibitors
- ACE2 Substrates
- ACE2 Proteins
- Angiotensins
- Antimicrobial Peptides
- Bradykinins
- Calpain Inhibitors
- Cathepsin and Thiol Protease Inhibitors
- Cytokines
- Defensins
- Furin Substrates and Inhibitors
- Interleukins
- RGD Peptides
- Serine Protease Substrates and Inhibitors
- SARS Related Products
- Trypsin (Substrates and Related)
Related Custom Services Categories
While a large part of the SARS-CoV-2 virus is made up of proteins, smaller fragments of these proteins are of equal interest. vivitide has over 50 years combined company experience in peptide synthesis and can aid in your research. Here are some of the ways we can aid in your research with custom peptide synthesis of:
- HLA-A*0201-Restricted Peptide Epitopes
- HLA-A*2402-Binding Peptides
- SARS-CoV-2 Nucleocapsid Fragments
- T-cell and B-cell Epitopes of SARS-CoV-2
- Furin Substrates and Inhibitors
- Fusion Inhibitors Targeting HR1 Domain of the SARS-CoV-2 Spike Proteins
- Substrates and Inhibitors of SARS-CoV-2 Mpro/3CLpro/C30 Endopeptidase
- Peptide Adjuvants like Toll-Like Receptor 4 (TLR-4) Agonist Peptides (example: Ala-Pro-Pro-His-Ala-Leu-Ser)
- ACE2 Inhibitors and Substrates
- AT2 Receptor Agonists and Antagonists
- TMPRSS2 Substrates and Inhibitors
- Tryptic Peptides related to the spike proteins and other viral components
If you have need of any other custom peptide synthesis, please visit:
Antibodies to Spike protein or ACE2 may also block important binding interactions and prevent infection. For more information on Custom Antibody development, please visit:
In addition, we also carry, from our catalog, related proteins (including the Nucleocapsid, S proteins), ACE2 substrates, protease inhibitors and more. Our COVID-19 Information Station is a convenient place for all of our updated news and related products. We wish you luck in your research endeavors, and most of all good health! Please contact us today if you are interested in a quote.
Related viviBlogs and viviNews
(The most recently added entries are at the top of this list)
- COVID-19 - Some Perspective 3/20/20
- An Open Letter to Our Customers: Coronavirus (COVID-19) Readiness 3/17/20
Product Brochures
(The most recently added or edited entries are at the top of this list)
- COVID-19 Product Brochure
- Angiotensin (AN) Peptides
- Enzyme Inhibitors
- Enzyme Substrates
- Synthetic and Microbial Inhibitors
Product Spotlights
(The most recently added entries are at the top of this list)
- Mini-Spotlight: A New Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Mpro - 4/28/20
- Mini-Spotlight: SARS-CoV-2 Mpro Protease Substrates - 3/31/20
- Product Spotlight: New Products, Including COVID-Items, By the Numbers - 3/20/20
- Mini-Spotlight: Camostat mesilate, seen to block SARS-CoV-2 or COVID-19 entry into human cells 3/18/20
viviNews
vivitide does not endorse or verify the information in these articles; they are provided as a service only. Some articles may require a subscription to view more than the abstract. Sorted by topic and some may appear in more than one category. (The most recently added entries are at the top of each category, date of addition here is after the entry, and some may not yet be peer-reviewed.)
January 2021
- A Novel ACE2 Isoform is Expressed in Human Respiratory Epithelia and is Upregulated in Response to Interferons and RNA Respiratory Virus Infection - 1/11/2021
- Short Form of ACE2 Upregulated by Interferon Therapy Lacks SARS-CoV-2 Binding Site - 1/11/2021
- Angiotensin-Converting Enzyme 2: From a Vasoactive Peptide to the Gatekeeper of a Global Pandemic - 1/7/2021
December 2020
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Dalbavancin Binds ACE2 to Block Its Interaction With SARS-CoV-2 Spike Protein and is Effective in Inhibiting SARS-CoV-2 Infection in Animal Model - 12/11/2020
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Little To No Expression of Angiotensin‐Converting Enzyme‐2 (ACE2) On Most Human Peripheral Blood Immune Cells But Highly Expressed On Tissue Macrophages - 12/10/2020
- The Gut Microbiome: An Under-Recognised Contributor to the COVID-19 Pandemic? - 12/7/2020
- SARS-CoV-2 Inhibition by Sulfonated Compounds - 12/7/2020
- Why is COVID-19 Less Severe in Children? A Review of the Proposed Mechanisms Underlying the Age-Related Difference in Severity of SARS-CoV-2 Infections - 12/4/2020
November 2020
- Regulation of SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs - 11/11/2020
October 2020
- Targeting Androgen Regulation of TMPRSS2 and ACE2 as a Therapeutic Strategy to Combat COVID-19 - 10/20/2020
- Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells - 10/5/2020
September 2020
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 - 9/22/2020 (PDF, pre-print)
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Activation of the SARS-CoV-2 Receptor Ace2 Through JAK/STAT-Dependent Enhancers During Pregnancy - 9/18/20
- COVID-19 Virus Uses Heparan Sulfate to Get Inside Cell - 9/16/2020
- The Inorganic Polymer, Polyphosphate, Blocks Binding of SARS-CoV-2 Spike Protein to ACE2 Receptor at Physiological Concentrations - 9/6/2020
- A Mechanistic Model and Therapeutic Interventions for COVID-19 Involving a RAS-Mediated Bradykinin Storm - 9/4/20
August 2020
- Elevated ACE2 Expression in the Olfactory Neuroepithelium: Implications for Anosmia and Upper Respiratory SARS-CoV-2 Entry and Replication - 8/31/2020
- Broad Host Range of SARS-CoV-2 Predicted By Comparative and Structural Analysis of ACE2 in Vertebrates - 8/27/2020
- Can We Fool SARS-CoV-2 With a Decoy Receptor for Cell Entry? - 8/10/2020
- ACE2, Metformin, and COVID-19 (pre-print) - 8/3/2020
July 2020
- Human iPSC-Derived Cardiomyocytes , are Susceptible to SARS-CoV-2 Infection - 7/2/2020
- Platelet Gene Expression and Function in COVID-19 Patients - 7/1/2020
June 2020
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The Use of Renin Angiotensin System Inhibitor on Mortality in Patients With Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis - 6/30/2020
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The Role of Angiotensin-Converting Enzyme 2 in The Pathogenesis of COVID-19: The Villain or The Hero? - 6/30/2020
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Inhibitors of Angiotensin-converting Enzyme or Blockers of Angiotensin-2 Receptor in COVID-19 Patients with Comorbid Cardiovascular or Pulmonary Diseases - 6/30/2020
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The Pivotal Link Between ACE2 Deficiency and SARS-CoV-2 Infection - 6/24/20
- Targeting ACE2 – Closing COVID-19’s Cellular Doorway - 6/1/2020
- The Enemy Within: How SARS-CoV-2 Uses Our Own Proteins to Infect Our Cells - 6/1/2020
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Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 - 6/1/2020
May 2020
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Are Patients With Hypertension and Diabetes Mellitus at Increased Risk for COVID-19 Infection? - 5/25/2020
- SARS-CoV-2 Entry Factors Are Highly Expressed in Nasal Epithelial Cells Together with Innate Immune Gene - 5/22/2020
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ACE2 Receptor Expression and Severe Acute Respiratory Syndrome Coronavirus Infection Depend on Differentiation of Human Airway Epithelia - 5/21/2020
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Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract - 5/21/2020
- SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and is Detected in Specific Cell Subsets Across Tissues - 5/5/2020
Previous Entries
- Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2
- Response to Recent Commentaries Regarding the Involvement of Angiotensin‐Converting Enzyme 2 (ACE2) and Renin‐Angiotensin System Blockers in SARS‐CoV‐2 infections
- SARS‐CoV‐2 Receptor ACE2 and TMPRSS2 Are Primarily Expressed in Bronchial Transient Secretory Cells
- New Drug Target Found for COVID-19
- An Experimental Peptide Could Block Covid-19
- Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia
- Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
ANTIMICROBIALS
Previous Entries
- Innovation Pharmaceuticals Provides Scientific Rationale and Clinical Development Perspectives for Brilacidin as a Potential Novel Coronavirus COVID-19 Treatment
- Current Treatment Options and the Role of Peptides as Potential Therapeutic Components for Middle East Respiratory Syndrome (MERS): A Review (potential SARS-CoV-2 applications)
- Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses
ANTIVIRALS and RELATED THERAPEUTICS
January 2021
- RNA Sequence and Ligand Binding Alter Conformational Profile of SARS-CoV-2 Stem Loop II Motif - 1/25/2021
- Potential Target for Anti-Viral Drugs To Treat COVID-19 - 1/25/2021
September 2020
- The Potential of Antimicrobial Peptides as an Antiviral Therapy against COVID-19 - 9/29/2020
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Potential Role of Peptide-Based Antiviral Therapy Against SARS-CoV-2 Infection - 9/29/2020
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Boceprevir, GC-376, and Calpain Inhibitors II, XII Inhibit SARS-CoV-2 Viral Replication by Targeting the Viral Main Protease- 9/18/20
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Peer-Reviewed Data Shows Remdesivir for COVID-19 Improves Time to Recovery - 9/28/2020
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An Alpaca Nanobody Neutralizes SARS-CoV-2 by Blocking Receptor Interaction - 9/10/2020
- Oromucosal Immunomodulation as Clinical Spectrum Mitigating Factor in SARS‐CoV‐2 Infection - 9/7/2020
July 2020
- Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike - 7/22/2020
- Boceprevir, GC-376, and Calpain Inhibitors II, XII Inhibit SARS-CoV-2 Viral Replication by Targeting the Viral Main Protease - 7/10/2020
May 2020
- NIH Launches Clinical Trial to Study Hydroxychloroquine Efficacy in COVID-19 - 5/15/20
- Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza - 5/5/2020
Previous Entries
- The Convalescent Sera Option for Containing COVID-19
- Prophylactic and Therapeutic Remdesivir (GS-5734) Treatment in the Rhesus Macaque Model of MERS-CoV Infection
December 2020
October 2020
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Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines - 10/20/2020
- Decoy Nanoparticles Protect Against COVID-19 by Concurrently Adsorbing Viruses and Inflammatory Cytokines - 10/15/2020
- De novo Design of Picomolar SARS-CoV-2 Miniprotein Inhibitors - 10/14/2020
September 2020
- Should We Unstress SARS-CoV-2 Infected Cells? - 9/22/2020
- The Immune Hallmarks of Severe COVID-19 - 9/17/2020
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Etoposide as Salvage Therapy for Cytokine Storm due to COVID-19 - 9/14/2020
- The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19 - 9/10/2020 (PDF)
August 2020
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COVID-19 Cytokine Storms May Prevent a Durable Immune Response - 8/31/2020
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How Covid Sends Some Bodies to War With Themselves - 8/17/2020
July 2020
- Novel Targeting Peptide Shows Promise Against COVID-19 Cytokine Storm - 7/10/2020
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The Emerging Spectrum of COVID-19 Neurology: Clinical, Radiological and Laboratory Findings - 7/7/2020
- Plasma IL-6 Levels following Corticosteroid Therapy as an Indicator of ICU Length of Stay in Critically ill COVID-19 Patients - 7/3/2020
June 2020
- Insights into the Use of C-Reactive Protein as a Diagnostic Index of Disease Severity in COVID-19 Infections - 6/30/2020
May 2020
- The Role of Cytokines Including Interleukin-6 in COVID-19 Induced Pneumonia and Macrophage Activation Syndrome-Like Disease - 5/26/20
- Storm Warning – The Critical Role of Cytokines in Severe COVID-19 - 5/19/2020
- An Outbreak of Severe Kawasaki-Like Disease at the Italian Epicentre of the SARS-CoV-2 Epidemic: an Observational Cohort Study - 5/18/2020
- Severe COVID-19: A Review of Recent Progress With a Look Toward the Future - 5/14/2020
- How COVID-19 Kills - 5/14/2020
- Longitudinal Peripheral Blood Transcriptional Analysis of COVID-19 Patients Captures Disease Progression and Reveals Potential Biomarkers - 5/8/2020 (preprint)
April 2020
- SARS-CoV-2: A Storm is Raging
- SARS-CoV-2 and Viral Sepsis: Observations and Hypotheses
- COVID-19: Immunopathology and its Implications for Therapy
- Why Some COVID-19 Cases Are Worse than Others
Previous Entries
- Breadth of Concomitant Immune Responses Prior to Patient Recovery: A Case Report of Non-Severe COVID-19
- COVID-19: Risk for Cytokine Targeting in Chronic Inflammatory Diseases?
November 2020
September 2020
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Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection - 9/23/20
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A New Screening Method for COVID-19 Based on Ocular Feature Recognition by Machine Learning Tools - 9/22/2020
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Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis - 9/14/2020
August 2020
- Modeling Study Flags Species Susceptible to SARS-CoV-2 - 8/27/2020
- Broad Host Range of SARS-CoV-2 Predicted By Comparative and Structural Analysis of ACE2 in Vertebrates - 8/27/2020
- Vitamin D Supplementation to Prevent Acute Respiratory Tract Infections: Systematic Review and Meta-Analysis of Individual Participant Data - 8/13/2020
June 2020
May 2020
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An Interactive Web-Based Dashboard to Track COVID-19 in Real Time - 5/18/2020
- Evidence From Internet Search Data Shows Information-Seeking Responses to News of Local COVID-19 Cases - 5/7/2020
April 2020
- Development of Epitope‐Based Peptide Vaccine Against Novel Coronavirus 2019 (SARS‐COV‐2): Immunoinformatics Approach
- App Concept Could Track Coronavirus Without Needing to Know Your Location
- Design of Multi Epitope-Based Peptide Vaccine Against E Protein of Human 2019-nCoV: An Immunoinformatics Approach (PDF)
- Citizen Scientists Are Helping Researchers Design New Drugs to Combat COVID-19
Previous Entries
- Time for NIH to Lead On Data Sharing
- COVID-19 Portal Will Provide Scientists Free Access to Completed Clinical Trial Data
- Scientists Use Online Game to Research COVID-19 Treatment
January 2021
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Myeloid Immune Cells in the Blood Tied to Severe COVID-19 - 1/27/2021
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Functional Monocytic Myeloid-Derived Suppressor Cells Increase in Blood But Not Airways and Predict COVID-19 Severity - 1/27/2021
- Circulating Myeloid Immune Cells Linked to Severe COVID-19 - 1/27/2021
- A Guide to Emerging SARS-CoV-2 Variants - 1/27/2021
- Immunological Characteristics Govern the Transition of COVID-19 to Endemicity - 1/26/2021 (PDF)
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COVID-19 One Year Later: The Biology and the Business - 1/26/2021
- SARS-CoV-2 Isn’t Going Away, Experts Predict - 1/26/2021
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Analysis Finds COVID-19 Infection May Provide Protective Immunity - 1/25/2021
- Neutralization of SARS-CoV-2 Lineage B.1.1.7 Pseudovirus by BNT162b2 Vaccine-Elicited Human Sera - 1/25/2021
- Study Investigates Potential Impact of Variant on COVID-19 Vaccine - 1/25/2021
- Talking Vitamin D and COVID-19 With Professor Adrian Martineau - 1/24/2021
- COVID-19 Model Reveals Key Role for Innate Immunity in Controlling Viral Load - 1/21/2021
- COVID-19’s Effects on the Brain - 1/21/2021
- COVID-19 One Year Later: The Biology and the Business - 1/20/2021
- Coronavirus Variant Linked to COVID-19 Outbreaks in California - 1/20/2021
- Past SARS-CoV-2 Infection Mostly Protects Survivors - 1/15/2021
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The Rapid, Massive Infection of the Scientific Literature and Authors by COVID-19 - 1/14/2021
- What’s Ahead for SARS-CoV-2 Research in 2021 - 1/14/2021
- Immunological Memory to SARS-CoV-2 Assessed For Up to 8 Months After Infection - 1/4/2021
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SARS-CoV-2 Immune Memory Measurable for Months Post-Infection - 1/4/2021
December 2020
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Common Genetic Variants Identify Therapeutic Targets for COVID-19 and Individuals at High Risk of Severe Disease - 12/15/2020
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Diagnostic Accuracy of Loop Mediated Isothermal Amplification Coupled to Nanopore Sequencing for the Detection of SARS-CoV-2 Infection at Scale in Symptomatic and Asymptomatic Populations - 12/14/2020
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Genetic Mechanisms of Critical Illness in Covid-19 - 12/13/2020
- Genes Could Be Key to New Covid-19 Treatments - 12/13/2020
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Epidemiological and Cohort Study Fnds No Association Between COVID-19 and Guillain-Barré Syndrome -12/13/2020
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How SARS-CoV-2 Hijacks and Rapidly Damages Human Lung Cells - 12/8/2020
- How the SARS-CoV-2 Virus Hijacks and Rapidly Causes Damage to Human Lung Cells - 12/8/2020
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SARS-CoV-2 Genetic Variant May Be More Transmissible - 12/8/2020
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Why is COVID-19 Less Severe in Children? A Review of the Proposed Mechanisms Underlying the Age-Related Difference in Severity of SARS-CoV-2 Infections - 12/4/2020
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Differences in Immunity and Blood Vessels Likely Protect Children From Severe COVID-19 - 12/4/2020
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SARS-CoV-2 Immune Cells Remain in Body, Providing Rapid Response to Re-infection - 12/3/2020
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Olfactory Transmucosal SARS-CoV-2 Invasion as a Port of Central Nervous System Entry in Individuals With COVID-19 -
12/1/2020
November 2020
- No Evidence For Increased Transmissibility From Recurrent Mutations in SARS-CoV-2 - 11/30/2020
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Previous SARS-CoV-2 Infection Prevents Reinfection for at Least 6 Months -11/23/2020
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Antibodies to SARS-CoV-2 Are Associated with Protection Against Reinfection - 11/22/2020
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Coronavirus Disease 2019 (COVID‐19): An Overview of the Immunopathology, Serological Diagnosis and Management - 11/20/2020
- Immunological Memory to SARS-CoV-2 Assessed For Greater Than Six Months After Infection - 11/18/2020
October 2020
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Persistence of Serum and Saliva Antibody Responses to SARS-CoV-2 Spike Antigens in COVID-19 Patients - 10/9/2020
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SARS-CoV-2 Infection of Human iPSC-Derived Cardiac Cells Predicts Novel Ccytopathic Features in Hearts of COVID-19 Patients - 10/8/2020
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What Does COVID-19 Do to the Nervous System? - 10/7/2020
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Reduced Development of COVID-19 in Children Reveals Molecular Checkpoints Gating Pathogenesis Illuminating Potential Therapeutics - 10/6/2020
September 2020
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Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37 - 9/29/2020
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Vast Majority in US Remain Susceptible to COVID-19: Study - 9/29/2020
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Inborn Errors of Type I IFN Immunity in Patients With Life-Threatening COVID-19 - 9/27/2020
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Auto-Antibodies Against Type I IFNs in Patients With Life-Threatening COVID-19 - 9/27/2020
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Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis - 9/24/2020
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Should We Unstress SARS-CoV-2 Infected Cells? - 9/22/2020
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Study Finds That Children's Immune Response Protects Against COVID-19 - 9/22/2020
- The Immune Hallmarks of Severe COVID-19 - 9/17/2020
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Venous Thromboembolism and Bleeding in Critically Ill COVID-19 Patients Treated With Higher Than Standard Low Molecular Weight Heparin Doses and Aspirin: A Call to Action - 9/17/2020
- Are SARS‐CoV‐2 IgA Antibodies in Pediatric Patients With Chilblain‐Like Lesions Indicative of COVID‐19 Asymptomatic or Paucisymptomatic Infection? - 9/17/2020
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Suboptimal SARS-CoV-2−Specific CD8+ T Cell Response Associated with the Prominent HLA-A*02:01 Phenotype -
9/16/2020 -
Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection - 9/15/2020
- Platelets and Renal Failure in the SARS-CoV-2 Syndrome - 9/8/2020
August 2020
- Elevated ACE2 Expression in the Olfactory Neuroepithelium: Implications for Anosmia and Upper Respiratory SARS-CoV-2 Entry and Replication - 8/27/2020
- Modeling Study Flags Species Susceptible to SARS-CoV-2 - 8/27/2020
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Pandemic Danger to the Deep: The Risk of Marine Mammals contracting SARS-CoV-2 From Wastewater - 8/27/2020
- Patients Reinfected with Coronavirus in Hong Kong, Europe - 8/26/2020
- COVID-19 Patients Exhibit Early Antibody Signatures Potentially Predictive of Death or Recovery - 8/14/2020
- Distinct Early Serological Signatures Track with SARS-CoV-2 Survival - 8/14/2020
- SARS-CoV-2-Reactive T Cells in Healthy Donors and Patients With COVID-19 - 8/13/2020
- Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence - 8/13/2020
- Vitamin D Supplementation to Prevent Acute Respiratory Tract Infections: Systematic Review and Meta-Analysis of Individual Participant Data - 8/13/2020
- Does the Common Cold Protect You from COVID-19? - 8/12/2020
- Presence of SARS-CoV-2 Reactive T Cells in COVID-19 Patients and Healthy Donors - 8/12/2020
- Antibodies in Serum of Convalescent Patients Following Mild COVID‐19 Do Not Always Prevent Virus Receptor Binding - 8/11/2020
July 2020
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Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival - 7/20/2020
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Systemic Hypoferremia and Severity of Hypoxemic Respiratory Failure in COVID-19 - 7/20/2020
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Neuroinvasive Potential of SARS-CoV-2 Revealed in a Human Brain Organoid Model - 7/17/2020
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Neurological complications of COVID-19 - 7/16/2020
- Neurological complications of COVID-19 Psychiatric and Neuropsychiatric Presentations Associated With Severe Coronavirus Infections: a Systematic Review and Meta-Analysis With Comparison to the COVID-19 Pandemic - 7/15/2020
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The Emerging Spectrum of COVID-19 Neurology: Clinical, Radiological and Laboratory Findings - 7/15/2020
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Opinion: What Models Can and Cannot Tell Us About COVID-19 - 7/14/2020
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Longitudinal Evaluation and Decline of Antibody Responses in SARS-CoV-2 Infection - 7/14/2020 (pre-print)
- SARS-CoV-2 Immunity Rapidly Declines Within Months of Infection - 7/14/2020
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Antibody vs Antigen Testing for COVID-19 - 7/14/2020
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Immunophenotyping of COVID-19 and Influenza Highlights the Role of Type I Interferons in Development of Severe COVID-19 - 7/13/2020
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Primary Exposure to SARS-CoV-2 Protects Against Reinfection in Rhesus Macaques - 7/9/2020
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Potential Causes and Consequences of Gastrointestinal Disorders During a SARS-CoV-2 Infection - 7/6/2020
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Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of the COVID-19 Virus - 7/6/2020
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Inside the Coronavirus - 7/2/2020
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Can a Vaccine for Covid-19 Be Developed in Record Time? - 7/1/2020
- Infectability of Human BrainSphere Neurons Suggests Neurotropism of SARS-CoV-2 - 7/1/2020
June 2020
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Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome - 6/30/2020
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Insights into the Use of C-Reactive Protein as a Diagnostic Index of Disease Severity in COVID-19 Infections - 6/30/2020
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Labs in the Time of COVID: An Early-Career Scientist's View - 6/23/2020
- Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections - 6/19/2020
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Neurochemical Evidence of Astrocytic and Neuronal Injury Commonly Found in COVID-19 - 6/19/2020
- Cellular Nanosponges Neutralize SARS-CoV-2 in Cell Culture - 6/18/2020
- Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity - 6/18/2020
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COVID ‐19: A Global Threat to the Nervous System - 6/12/2020
- Why COVID-19 Is a Threat to the Entire Nervous System - 6/12/2020
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Sex Differences in Immune Responses to SARS-CoV-2 That Underlie Disease Outcomes - 6/11/2020 (pre-print)
- The Genetic Basis of COVID-19 Susceptibility - 6/10/2020
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The ABO Blood Group Locus and a Chromosome 3 Gene Cluster Associate with SARS-CoV-2 Respiratory Failure in an Italian-Spanish Genome-Wide Association Analysis - 6/8/2020 (pre-print)
- Genes May Leave Some People More Vulnerable to Severe Covid-19 - 6/7/2020
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SARS-CoV-2 Infection Mapped through Respiratory Tract - 6/3/2020
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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract - 6/3/2020 (PDF)
- Distant Sequence Similarity Between Hepcidin and the Novel Coronavirus Spike
May 2020
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Glycoprotein: a Potential Hint at the Possibility of Local Iron Dysregulation in COVID-19 - 5/26/2020 (PDF)
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A Journey Through and Beyond a “Perfect Storm”: The COVID-19 Pandemic - 5/24/2020
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COVID-19 and Endocrine Diseases. A Statement Fom the European Society of Endocrinology - 5/24/2020
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A Deadly Virus is Killing Wild Rabbits in North America - 5/22/2020
- A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing - 5/22/2020
- Hunting for a SARS-CoV-2 Biomarker with Metabolomics - 5/21/2020
- A Matter of Time: Duration and Choice of Venous Thromboprophylaxis in Patients Diagnosed with COVID-19 - 5/21/2020
- The Airborne Lifetime of Small Speech Droplets and Their Potential Importance in SARS-CoV-2 Transmission - 5/19/2020
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The Most Eagerly Awaited Summer of the Anthropocene: A Perspective of SARS-CoV-2 Decay and Seasonal Change - 5/18/2020
- How COVID-19 Kills - 5/14/2020
- Severe COVID-19: A Review of Recent Progress With a Look Toward the Future - 5/14/2020
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Bat 'Super Immunity' May Explain How Bats Carry Coronaviruses—U. of Saskatchewan Study - 5/7/2020
April 2020
- Patients With Cancer Appear More Vulnerable to SARS-COV-2: a Multi-Center Study During the COVID-19 Outbreak - 4/28/2020
Previous Entries
- Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection
- UAB Team Joins Search for Drugs Effective Against COVID-19
- Rockefeller Scientists Launch a Broad Range of Studies into Novel Coronavirus
- SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease
- Evidence for Gastrointestinal Infection of SARS-CoV-2
- Clinical Features of COVID-19-Related Liver Damage
- Coronavirus Infection and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity
- Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection
- Spread of Early Coronavirus Lineages Reconstructed Using Genetic Network Technique
- COVID-19 and The Cardiovascular System
- The Reproductive Number of COVID-19 is Higher Compared to SARS Coronavirus
- COVID-19: Consider Cytokine Storm Syndromes and Immunosuppression
- What Cells Does The Novel Coronavirus Attack?
- How the Coronavirus Outbreak Is Impacting Research
- The Proximal Origin of SARS-CoV-2
- Scientist Proposes Clinical Trials w/ Low-Dose Rapamycin to Protect Elderly From COVID-19
- How Coronavirus Attacks the Body
- Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study
- Study Identifies Characteristics of Patients with Fatal COVID-19
- Tackling COVID-19: Ongoing Drug Development Efforts
- Avoiding Pitfalls in the Pursuit of a COVID-19 Vaccine
- Covid-19 — Navigating the Uncharted
PEPTIDES & CORONAVIRUSES
January 2021
- SARS-CoV-2 Mpro Inhibitors and Activity-Based Probes for Patient-Sample Imaging - 1/22/2021 (see INH-3253-v)
- The Vasoactive Peptide MR-Pro-Adrenomedullin in COVID-19 Patients: an Observational Study (PDF) - 1/13/2021
- The Landscape of Antibody Binding in SARS-CoV-2 Infection (SARS-CoV-2 Antibody Binding Landscape) (PDF) - 1/12/2021
- The Prognostic Effect of Brain Natriuretic Peptide Levels on Outcomes of Hospitalized Patients with COVID-19 - 1/8/2021
December 2020
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Identifying Epitopes for Cluster of Differentiation and Design of New Peptides Inhibitors Against Human SARS-CoV-2 Spike RBD by an In-Silico Approach - 12/16/2020
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Viral Nucleoprotein Antibodies Activate TRIM21 and Induce T Cell Immunity - 12/11/2020
- Dalbavancin Binds ACE2 to Block Its Interaction With SARS-CoV-2 Spike Protein and is Effective in Inhibiting SARS-CoV-2 Infection in Animal Model - 12/11/2020
- SARS-CoV-2 Drug Discovery based on Intrinsically Disordered Regions - 12/3/2020
November 2020
- Charged Amino Acids May Promote Coronavirus SARS-CoV-2 Fusion With the Host Cell - 11/30/2020
- Identification of a Membrane Binding Peptide in the Envelope Protein of MHV Coronavirus - 11/30/2020
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Detection, Mapping, and Proteotyping of SARS-CoV-2 Coronavirus with High Resolution Mass Spectrometry - 11/18/2020
- Computational Design of 25-mer Peptide Binders of SARS-CoV-2 - 11/17/2020
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A Multiple Peptides Vaccine against COVID-19 Designed from the Nucleocapsid phosphoprotein (N) and Spike Glycoprotein (S) via the Immunoinformatics Approach - 11/15/2020
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B-type Natriuretic Peptide and Prognosis of Covid-19 in New York City - 11/14/2020
- Peptide and Peptide-Based Inhibitors of SARS-CoV-2 Entry - 11/13/2020
- Elevated Natriuretic Peptides in Covid-19 Patients With Severe or Critical Illness - 11/12/2020
October 2020
September 2020
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The Potential of Antimicrobial Peptides as an Antiviral Therapy against COVID-19 - 9/29/2020
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Potential Role of Peptide-Based Antiviral Therapy Against SARS-CoV-2 Infection - 9/29/2020
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Boceprevir, GC-376, and Calpain Inhibitors II, XII Inhibit SARS-CoV-2 Viral Replication by Targeting the Viral Main Protease- 9/18/20
- Suboptimal SARS-CoV-2−Specific CD8+ T Cell Response Associated with the Prominent HLA-A*02:01 Phenotype -9/16/2020
July 2020
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The Discovery of a Putative Allosteric Site in the SARS-CoV-2 Spike Protein Using an Integrated Structural/Dynamic Approach - 7/20/20
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Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival - 7/20/2020
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Systemic Hypoferremia and Severity of Hypoxemic Respiratory Failure in COVID-19 - 7/20/2020
- Boceprevir, GC-376, and Calpain Inhibitors II, XII Inhibit SARS-CoV-2 Viral Replication by Targeting the Viral Main Protease - 7/10/2020
- Novel Targeting Peptide Shows Promise Against COVID-19 Cytokine Storm - 7/10/2020
June 2020
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Broad and Strong Memory CD4+ and CD8+ T Cells Induced by SARS-CoV-2 in UK Convalescent COVID-19 Patients - 6/29/2020
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SARS‐CoV‐2‐Reactive Interferon‐γ‐Producing CD8+ T Cells in Patients Hospitalized with Coronavirus Disease 2019 - 6/29/2020
- Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 - 6/1/2020
- Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics Approach - 6/1/2020
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Peptide-Like and Small-Molecule Inhibitors Against Covid-19 - 6/1/2020
April 2020
- Gold Standard Force Fields Help Identify Promising Peptides to Disrupt COVID-19 - 4/30/2020
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In Silico Identification of Novel B Cell and T Cell Epitopes of Wuhan Coronavirus (2019-nCoV) for Effective Multi Epitope-Based Peptide Vaccine Production (PDF) - 4/29/2020
- A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Corona Virus Disease 2019 (COVID-19) (PDF) - 4/29/2020
- Therapeutic and Prophylactic Potential of Anti-Microbial Peptides Against Coronaviruses - 4/29/2020
- Design of a Peptide-Based Subunit Vaccine Against Novel Coronavirus SARS-CoV-2 (PDF) - 4/27/2020
PROTEOMICS
August 2020
- Proteolytic Cleavage of the SARS-CoV-2 SpikeProtein and the Role of the Novel S1/S2 Site - 8/19/2020
- Mass Spectrometric Identification of SARS-CoV‑2 Proteins from Gargle Solution Samples of COVID-19 Patients - 8/18/2020
- In Silico Approach Toward the Identification of Unique Peptides From Viral Protein Infection: Application to COVID-19 -8/18/20
RESOURCES
January 2021
- A Guide to Emerging SARS-CoV-2 Variants - 1/27/2021
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COVID-19 One Year Later: The Biology and the Business - 1/26/2021
- SARS-CoV-2 Isn’t Going Away, Experts Predict - 1/26/2021
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Ventilator-Associated Pneumonia in Critically Ill Patients With COVID-19a - 1/23/2021
- Test Can Quickly Identify Pneumonia in Patients With Severe COVID-19 - 1/23/2021
- COVID-19 Model Reveals Key Role for Innate Immunity in Controlling Viral Load - 1/21/2021
- COVID-19’s Effects on the Brain - 1/21/2021
- COVID-19 One Year Later: The Biology and the Business - 1/20/2021
- Coronavirus Variant Linked to COVID-19 Outbreaks in California - 1/20/2021
- Past SARS-CoV-2 Infection Mostly Protects Survivors - 1/15/2021
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Could COVID-19 Trigger Chronic Disease in Some People? - 1/10/2021
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What’s Ahead for SARS-CoV-2 Research in 2021 - 1/10/2021
- Infographic: How SARS-CoV-2 Might Travel from Mom to Fetus - 1/9/2021
- Human Fetuses Can Contract SARS-CoV-2, but It’s Rare - 1/9/2021
- SARS-CoV-2 Immune Memory Measurable for Months Post-Infection - 1/8/2021
December 2020
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Reliable COVID-19 Test Could Reduce Virus Spread - 12/21/2020
- New COVID-19 Test Could Cut False Negatives and Deliver Faster Results - 12/21/2020
- Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip - 12/9/2020
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Paper-Based Electrochemical Sensor Can Detect COVID-19 in Less than Five Minutes - 12/9/2020
- Olfactory Transmucosal SARS-CoV-2 Invasion as a Port of Central Nervous System Entry in Individuals With COVID-19 - 12/1/2020
November 2020
- Coronavirus Disease 2019 (COVID‐19): An Overview of the Immunopathology, Serological Diagnosis and Management - 11/20/2020
- Immunological Memory to SARS-CoV-2 Assessed For Greater Than Six Months After Infection - 11/18/2020
October 2020
- Neuropilin-1 is a Host Factor for SARS-CoV-2 Infection - 10/22/2020
- “Silent” Mutations Helped SARS-CoV-2 Thrive Once It Made the Leap to Humans - 10/21/2020
- Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines - 10/20/2020
- What Does COVID-19 Do to the Nervous System? - 10/7/2020
September 2020
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Pathological Features of COVID-19-Associated Myocardial Injury: A Multicentre Cardiovascular Pathology Study - 9/28/2020
- A New Way To Characterize Glycans From SARS-CoV-2's Spike Protein - 9/23/2020
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The Immune Hallmarks of Severe COVID-19 - 9/17/2020
- Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis - 9/14/2020
- The Kinetics of Viral Load and Antibodies to SARS-CoV-2 - 9/9/2020
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Cell and Animal Models of SARS-CoV-2 Pathogenesis and Immunity - 9/1/2020
- Age Differences in Risk and Resilience Factors in COVID-19-Related Stress - 9/1/2020
August 2020
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Distinct Early Serological Signatures Track with SARS-CoV-2 Survival - 8/27/2020 (PDF)
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Robust T Cell Immunity in Convalescent Individuals With Asymptomatic or Mild COVID-19 - 8/17/2020 (PDF)
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Detection, Prevalence, and Duration of Humoral Responses to SARS-CoV-2 Under Conditions of Limited Population Exposure - 8/17/2020
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Dynamics and Significance of the Antibody Response to SARS-CoV-2 Infection - 8/16/2020
- Only Around 60% of Recovered COVID-19 Patients Develop Protective Antibodies - 8/10/2020
July 2020
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Neurochemical Evidence of Astrocytic and Neuronal Injury Commonly Found in COVID-19 - 7/28/2020
- The Landscape of SARS-CoV-2 RNA Modifications - 7/23/2020
June 2020
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Biosafety at Home: How to Translate Biomedical Laboratory Safety Precautions for Everyday Use in the Context of COVID-19 - 6/30/2020
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COVID-19 Drug & Vaccine Candidate Tracker - 6/16/2020
- A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies - 6/11/2020
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COVID-19 Mouse Model Created To Accelerate Drug and Vaccine Development - 6/11/2020
- RosettaMHC models of SARS-CoV-2 peptide/HLA-A02 antigens - 6/9/20
May 2020
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A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing - 5/22/2020
- SARS-CoV-2 Protein Interaction Map Reveals Drug Targets - 5/22/2020
- How Does Coronavirus Kill? Clinicians Trace a Ferocious Rampage Through the Body, from Brain to Toes
- NIH Begins Study to Quantify Undetected Cases of Coronavirus Infection
- Global Coronavirus COVID-19 Clinical Trial Tracker
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ClinicalTrials.gov: A Listing of Clinical Trials Relating to COVID-19 (US National Library of Medicine)
- Living Paper: Coronavirus COVID-19
- Communication Resources from NIH About Coronavirus
- COVID-19 Resources and News Page From the American Society for Biochemistry and Molecular Biology
- Catching Up to Coronavirus: Top 60 Treatments in Development
- Aiding COVID-19 Data Analysis: Uniform Analysis of Coronavirus and SARS-COV-2 Nanopore Direct RNA Sequencing Datasets Using MasterOfPores
- COVID-19 Docking Server: An Interactive Server for Docking Small Molecules, Peptides and Antibodies Against Potential Targets of COVID-19
SARS-CoV-2 MAIN PROTEASE (Mpro)/ENDOPEPTIDASE C30/3CLpro
January 2021
Previous Entries
- Boceprevir, GC-376, and Calpain Inhibitors II, XII Inhibit SARS-CoV-2 Viral Replication by Targeting the Viral Main Protease - 7/10/2020
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Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-Digallate (TF3)
December 2020
November 2020
- Structure and Drug Binding of the SARS-CoV-2 Envelope Protein Transmembrane Domain in Lipid Bilayers - 11/11/2020
October 2020
- The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET - 10/16/2020
September 2020
- A New Way To Characterize Glycans From SARS-CoV-2's Spike Protein - 9/25/2020
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Molecular Architecture of the SARS-CoV-2 Virus - 9/18/20
July 2020
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Structural Basis of RNA Cap Modification by SARS-CoV-2 - 7/23/2020
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Mutated Form of SARS-CoV-2 Is Dominant, But Doesn't Make Patients Sicker, Study Says - 7/6/2020
- Newer, More Dominant COVID-19 Variant Is More Infectious in the Lab - 7/6/2020
- Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of the COVID-19 Virus - 7/6/2020
June 2020
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A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells - 6/22/20
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The Genetic Basis of COVID-19 Susceptibility - 6/10/2020
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Phylogenetic Network Analysis of SARS-CoV-2 Genomes - 6/5/2020
- SARS-CoV-2 Spike Protein Shares Sequence with a Human Protein - 6/3/2020
May 2020
- Structure of Replicating SARS-CoV-2 Polymerase - 5/21/2020
- Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop - 5/18/2020
- Unveiling the Structure of SARS-CoV-2 - 5/11/2020
- Cryo-EM Analysis of a Feline Coronavirus Spike Protein Reveals a Unique Structure and Camouflaging Gycan - 5/7/2020
- Phylogenetic Network Analysis of SARS-CoV-2 Genomes - 5/7/2020
- Rapid Reconstruction of SARS-CoV-2 Using a Synthetic Genomics Platform - 5/5/2020
Previous Entries
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- A Study of Nonstructural Protein 1 of SARS Coronavirus
- The Architecture of SARS-CoV-2 Transcriptome (PDF)
- Coronavirus Genomic and Subgenomic RNA Architecture Mapped
- Bad News Wrapped in Protein: Inside the Coronavirus Genome
- Report: A Highly conserved Cryptic Epitope in the Receptor-Binding Domains of SARS-CoV-2 and SARS-CoV
- Crystal Structure of Nsp15 Endoribonuclease NendoU from SARS-CoV-2
September 2020
July 2020
- Evolutionary Origins of the SARS-CoV-2 Sarbecovirus Lineage Responsible for the COVID-19 Pandemic - 7/24/2020
June 2020
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Analysis of Hospital Traffic and Search Engine Data in Wuhan China Indicates Early Disease Activity in the Fall of 2019 - 6/10/2020
- SARS-CoV-2 Could Have Been in Wuhan Last Summer, According to Harvard Study - 6/10/2020
May 2020
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The Epidemiology and Pathogenesis of Coronavirus Disease (COVID-19) Outbreak - 5/18/2020
- Bat 'Super Immunity' May Explain How Bats Carry Coronaviruses—U. of Saskatchewan Study - 5/7/2020
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Selection of Viral Variants During Persistent Infection of Insectivorous Bat Cells with Middle East Respiratory Syndrome Coronavirus - 5/7/2020 (PDF)
- A Genomic Perspective on the Origin and Emergence of SARS-CoV-2
January 2021
- SARS-CoV-2 Mpro Inhibitors and Activity-Based Probes for Patient-Sample Imaging - 1/22/2021 (see INH-3253-v)
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Evidence for Adaptive Evolution in the Receptor-Binding Domain of Seasonal Coronaviruses OC43 and 229E - 1/19/2021
- Seasonal Coronaviruses’ Spike Proteins Evolve to Evade Immune Responses - 1/19/2021
December 2020
- Dalbavancin Binds ACE2 to Block Its Interaction With SARS-CoV-2 Spike Protein and is Effective in Inhibiting SARS-CoV-2 Infection in Animal Model - 12/11/2020
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Looking Beyond the Spike Protein for SARS-CoV-2 Vaccine Design - 12/2/2020
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Olfactory Transmucosal SARS-CoV-2 Invasion as a Port of Central Nervous System Entry in Individuals With COVID-19 -
12/1/2020
November 2020
October 2020
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Neuropilin-1 is a Host Factor for SARS-CoV-2 Infection - 10/22/2020
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A New Way To Characterize Glycans From SARS-CoV-2's Spike Protein - 10/21/2020
- Structure, Dynamics, Receptor Binding, and Antibody Binding of Fully-glycosylated Full-length SARS-CoV-2 Spike Protein in a Viral Membrane - 10/19/2020
- The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM and Cryo-ET - 10/16/2020
September 2020
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A New Way To Characterize Glycans From SARS-CoV-2's Spike Protein - 9/25/2020
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Free Fatty Acid Binding Pocket in the Locked Structure of SARS-CoV-2 Spike Protein - 9/24/2020
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A New Way To Characterize Glycans From SARS-CoV-2's Spike Protein - 9/23/2020
- Boceprevir, GC-376, and Calpain Inhibitors II, XII Inhibit SARS-CoV-2 Viral Replication by Targeting the Viral Main Protease- 9/18/20
- Vitamin D Binding Protein Polymorphism and COVID‐19 - 9/14/2020
- An Alpaca Nanobody Neutralizes SARS-CoV-2 by Blocking Receptor Interaction - 9/10/2020
- De novo Design of Picomolar SARS-CoV-2 Miniprotein Inhibitors - 9/10/2020
- Selective Inhibition of Thromboinflammation in COVID-19 by Btk Inhibitors - 9/8/2020
- The Inorganic Polymer, Polyphosphate, Blocks Binding of SARS-CoV-2 Spike Protein to ACE2 Receptor at Physiological Concentrations - 9/6/2020
August 2020
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Elevated ACE2 Expression in the Olfactory Neuroepithelium: Implications for Anosmia and Upper Respiratory SARS-CoV-2 Entry and Replication - 8/31/2020
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Antibodies in Serum of Convalescent Patients Following Mild COVID‐19 Do Not Always Prevent Virus Receptor Binding - 8/11/2020
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Can We Fool SARS-CoV-2 With a Decoy Receptor for Cell Entry? - 8/10/2020
- Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection - 8/3/2020
- Fruitful Neutralizing Antibody Pipeline Brings Hope to Defeat SARS-Cov-2 - 8/3/2020
July 2020
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Structural Plasticity of SARS-CoV-2 3CL Mpro Active Site Cavity Revealed by Room Temperature X-ray Crystallography - 7/29/2020
- Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike - 7/22/2020
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The Discovery of a Putative Allosteric Site in the SARS-CoV-2 Spike Protein Using an Integrated Structural/Dynamic Approach - 7/20/20
- Tracking Changes in SARS-CoV-2 Spike: Evidence That D614G Increases Infectivity of the COVID-19 Virus - 7/6/2020
- Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear - 7/3/2020
- Platelet Gene Expression and Function in COVID-19 Patients - 7/1/2020
June 2020
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This Coronavirus Mutation Has Taken Over the World. Scientists Are Trying to Understand Why - 6/29/2020
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Neutralisation of SARS-CoV-2 by Destruction of the Prefusion Spike - 6/22/20
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The D614G Mutation in the SARS-CoV-2 Spike Protein Reduces S1 Shedding and Increases Infectivity - 6/16//2020
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The Receptor Binding Domain of the Viral Spike Protein Is an Immunodominant and Highly Specific Target of Antibodies in SARS-CoV-2 Patients - 6/15/2020
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Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atom Simulations - 6/10/2020
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Cell Entry Mechanisms of SARS-CoV-2 - 6/5/2020
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Coronavirus Endoribonuclease Targets VIral Polyuridine Sequences to Evade Activating Host Sensors - 6/4/2020
- SARS-CoV-2 Spike Protein Shares Sequence with a Human Protein - 6/3/2020
- Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming - 6/3/2020
May 2020
- A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing - 5/22/2020
- SARS-CoV-2 Protein Interaction Map Reveals Drug Targets - 5/22/2020
- Molecular Docking Study of COVID-19 Main Protease with Clinically Approved Drugs - 5/19/2020 (preprint)
- Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop - 5/18/2020
- Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation - 5/11/2020
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Broad Receptor Engagement of an Emerging Global Coronavirus May Potentiate its Diverse Cross-Species Transmissibility - 5/7/2020
- Human Coronaviruses OC43 and HKU1 Bind to 9-O-aAcetylated Sialic Acids Via a Conserved Receptor-Binding Site in Spike Protein Domain A - 5/7/2020
- Enhanced Isolation of SARS-CoV-2 by TMPRSS2-Expressing Cells - 5/7/2020
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Coronavirus Endoribonuclease Targets Viral Polyuridine Sequences to Evade Activating Host Sensors - 5/7/2020
- SARS-CoV-2 Entry Factors Are Highly Expressed in Nasal Epithelial Cells Together with Innate Immune Genes - 5/5/2020
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A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing - 5/5/2020
- SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and is Detected in Specific Cell Subsets Across Tissues - 5/5/2020
April 2020
- A Potential Role for Integrins in Host Cell Entry by SARS-CoV-2
- An Evolutionary RGD Motif in the Spike Protein of SARS-CoV-2 may Serve as a Potential High Risk Factor for Virus Infection? (pre-print)
- Peptide Therapies Could Disable Coronavirus’ Spike Proteins
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
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Cell Adhesion as a Novel Approach to Determining the Cellular Binding Motif on the Severe Acute Respiratory Syndrome Coronavirus Spike Protein
Previous Entries
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The Spike Protein of SARS-CoV — A Target for Vaccine and Therapeutic Development
- Characterization of Spike Glycoprotein of SARS-CoV-2 on Virus Entry and its Immune Cross-Reactivity with SARS-CoV
- Potent Binding of 2019 Novel Coronavirus Spike Protein by a SARS Coronavirus-Specific Human Monoclonal Antibody
- Coronaviruses Hijack The Complement System
- SARS‐CoV‐2 Receptor ACE2 and TMPRSS2 Are Primarily Expressed in Bronchial Transient Secretory Cells
- COVID-19 Drug Candidates Found by Targeting the Viral Protease
- Possible SARS-CoV-2 Vulnerability Revealed by Human Antibody
- What Cells Does The Novel Coronavirus Attack?
- A Highly Conserved Cryptic Epitope in the Receptor-Binding Domains of SARS-CoV-2 and SARS-CoV
- Clues to COVID-19 Coronavirus’s Vulnerability Emerge From An Antibody Against SARS
- COVID-19 Spike-Host Cell Receptor GRP78 Binding Site Prediction
- A Human Monoclonal Antibody Blocking SARS-CoV-2 Infection
- The First-in-Class Peptide Binder to the SARS-CoV-2 Spike Protein
- Potential T-cell and B-cell Epitopes of 2019-nCoV
- Cleavage of Group 1 Coronavirus Spike Proteins: How Furin Cleavage Is Traded Off against Heparan Sulfate Binding upon Cell Culture Adaptation
- The Spike Glycoprotein of the New Coronavirus 2019-nCoV Contains a Furin-Like Cleavage Site Absent in CoV of the Same Clade
- The Proximal Origin of SARS-CoV-2
SERINE PROTEASE TYPE II TRANSMEMBRANE SERINE PROTEASE (TMPRSS2) INHIBITION
October 2020
- Targeting Androgen Regulation of TMPRSS2 and ACE2 as a Therapeutic Strategy to Combat COVID-19 - 10/20/2020
- Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells - 10/5/2020
July 2020
- Targeting TMPRSS2 in SARS-CoV-2 Infection - 7/23/2020
May 2020
- Candidate Drugs Against SARS-CoV-2 and COVID-19 - 5/22/2020
- TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention? - 5/22/2020
April 2020
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor - 4/16/2020
- Enhanced Isolation of SARS-CoV-2 by TMPRSS2-Expressing Cells
VACCINE, THERAPIES, and OTHER RELATED TREATMENTS
January 2021
- Eli Lilly, Regeneron Report Positive Phase III COVID-19 Antibody Results - 1/27/2021
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Moderna Developing Booster Shot for New Virus Variant B.1.351 - 1/26/2021
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Plitidepsin Has Potent Preclinical Efficacy Against SARS-CoV-2 by Targeting the Host Protein eEF1A - 1/26/2021
- Plitidepsin Shows Promise against SARS-CoV-2 in Preclinical Models - 1/26/2021
- Study Investigates Potential Impact of Variant on COVID-19 Vaccine - 1/25/2021
- UK Approves Arthritis Drugs for Critically Ill COVID-19 Patients - 1/12/2021
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Study Finds Shortened Telomeres in Patients With Severe COVID-19
- 1/12/2021 - CoViTris2020 and ChloViD2020: A Striking New Hope in COVID-19 Therapy - 1/6/2021
December 2020
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Drug Could Help To Improve Vaccine Response in Older Adults - 12/18/2020
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Baricitinib Plus Remdesivir For Hospitalized Adults With Covid-19 - 12/13/2020
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Treating COVID-19: Baricitinib Plus Remdesivir Shows Promise in Trial - 12/13/2020
- Baricitinib Plus Remdesivir Shows Promise for Treating COVID-19 - 12/13/2020
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FDA-Approved Drugs with Potent In Vitro Antiviral Activity Against Severe Acute Respiratory Syndrome Coronavirus - 12/11/2020
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Correlates of Protection Against SARS-CoV-2 in Rhesus Macaques - 12/8/2020
- Key Questions and Answers About the UK's First Approved COVID-19 Vaccine - 12/8/2020
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Oral Drug Blocks SARS-CoV-2 Transmission, Georgia State Biomedical Sciences Researchers Find - 12/7/2020
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New Drug Rapidly Blocks SARS-CoV-2 Transmission in Animal Model - 12/7/2020
- Looking Beyond the Spike Protein for SARS-CoV-2 Vaccine Design - 12/2/2020
November 2020
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AstraZeneca-Oxford COVID-19 Vaccine Shows Positive Phase II Results - 11/23/2020
- Moderna COVID-19 Vaccine 94.5% Effective in Early Phase III Data - 11/20/2020
- Pfizer, BioNTech Report 95% Final Efficacy for COVID-19 Vaccine - 11/18/2020
October 2020
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CBD Could Treat Inflammation Caused by COVID-19, Study Shows - 10/22/2020
- Cannabidiol Modulates Cytokine Storm in Acute Respiratory Distress Syndrome Induced by Simulated Viral Infection Using Synthetic RNA - 10/22/2020
- Peptide Vaccine Candidate Mimics the Heterogeneity of Natural SARS-CoV-2 Immunity in Convalescent Humans and Induces Broad T Cell Responses in Mice Models - 10/16/2020
- Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity - 10/2/2020
September 2020
- Peer-Reviewed Data Shows Remdesivir for COVID-19 Improves Time to Recovery - 9/25/2020
- Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients with COVID-19: A Meta-analysis - 9/4/20
August 2020
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A Rapidly Adaptable Biomaterial Vaccine for SARS-CoV-2 - 8/24/2020 (PDF)
- SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) – A Drug Repurposing Study - 8/3/2020
- A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses Against SARS-CoV-2 in Mice - 8/3/2020
July 2020
- First Volunteers Receive Imperial COVID-19 Vaccine - 7/30/2020
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A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition - 7/6/2020
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Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells - 7/6/2020
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A Universal Design of Betacoronavirus Vaccines Against COVID-19, MERS and SARS - 7/6/2020
- Robust T Cell Immunity in Convalescent Individuals With Asymptomatic or Mild COVID-19 - 7/2/2020
- Can a Vaccine for Covid-19 Be Developed in Record Time? - 7/1/2020
June 2020
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Snakes Alive: Venom May Play a Role in the Fight Against COVID-19 - 6/23/2020
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The Old But New: Can Unfractioned Heparin and Low Molecular Weight Heparins Inhibit Proteolytic Activation and Cellular Internalization of SARS-CoV2 by Inhibition of Host Cell Proteases? - 6/23/2020
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FDA Repeals Emergency Use Authorization for Hydroxychloroquine, Chloroquine - 6/16/2020
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COVID-19 Vaccine Candidate Front Runners - 6/16/2020
- COVID-19 Drug & Vaccine Candidate Tracker - 6/16/2020
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Cow-Derived COVID-19 Candidate Treatment Produces Four Times More Neutralizing Antibody, Suggests Data - 6/15/2020
- The Receptor Binding Domain of the Viral Spike Protein Is an Immunodominant and Highly Specific Target of Antibodies in SARS-CoV-2 Patients - 6/15/2020
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A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies - 6/11/2020
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COVID-19 Mouse Model Created To Accelerate Drug and Vaccine Development - 6/11/2020
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Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-term Population-Scale Immunity - 6/10/2020
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Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming - 6/3/2020
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Effective SARS-CoV-2 Neutralizing Antibodies Found – Major Milestone in the Fight Against COVID-19 - 6/3/2020
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First Antibody Trial Launched in COVID-19 Patients - 6/3/2020
- Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics Approach - 6/1/2020
May 2020
- Rapid repurposing of drugs for COVID-19 - 5/26/20
- Ligand-centered Assessment of SARS-CoV-2 Drug Target Models in the Protein Data Bank - 5/26/20
- A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2 - 5/26/20
- Candidate Drugs Against SARS-CoV-2 and COVID-19 - 5/22/2020
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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals - 5/18/2020
- Good News for COVID-19 Vaccine: Immune System Shows Robust Response to SARS-CoV-2 - 5/18/2020
- Natural Experiment Concept to Accelerate the Re-Purposing of Existing Therapeutics for Covid-19 - 5/18/2020
- Moderna Coronavirus Vaccine Trial Shows Promising Early Results - 5/18/2020
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Design of a Peptide-Based Subunit Vaccine Against Novel Coronavirus SARS-CoV-2 (PDF)
- Epitope-Based Peptide Vaccine Design and Target Site Characterization Against Novel Coronavirus Disease Caused by SARS-CoV-2
- Development of Epitope‐Based Peptide Vaccine Against Novel Coronavirus 2019 (SARS‐COV‐2): Immunoinformatics Approach
April 2020
- COVID-19 Coronavirus Spike Protein Analysis for Synthetic Vaccines, a Peptidomimetic Antagonist, and Therapeutic Drugs, and Analysis of a Proposed Achilles’ Heel Conserved Region to Minimize Probability of Escape Mutations and Drug Resistance
- COVID-19 Drug Candidates Found by Targeting the Viral Protease
- Possible SARS-CoV-2 Vulnerability Revealed by Human Antibody
- Which Vaccines Against COVID-19 Are in Human Clinical Trials?
- Microneedle Array Delivered Recombinant Coronavirus Vaccines: Immunogenicity and Rapid Translational Development
Previous Entries
- Clues to COVID-19 Coronavirus’s Vulnerability Emerge From An Antibody Against SARS
- Report: A Highly Conserved Cryptic Epitope in the Receptor-Binding Domains of SARS-CoV-2 and SARS-CoV
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COVID-19 Vaccine Candidate Shows Promise and COVID-19 Vaccine Candidate Shows Promise in First Peer-Reviewed Research
- BAT Working on Potential COVID-19 Vaccine Through US Bio-Tech Subsidiary
- First Report of Human Monoclonal Antibody That Blocks SARS-CoV-2
- Experts Weigh in on Vaccine Prospects as Dozens of COVID-19 Projects Race Ahead
- Avoiding Pitfalls in the Pursuit of a COVID-19 Vaccine
- Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases
- An Effective CTL Peptide Vaccine for Ebola Zaire Based on Survivors’ CD8+ Targeting of a Particular Nucleocapsid Protein Epitope with Potential Implications for COVID-19 Vaccine Design
- Personalized Workflow to Identify Optimal T-cell Epitopes for Peptide-Based Vaccines Against COVID-19
- Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases
- Current Efforts in COVID-19 Vaccine Development
- Synthetic Toll Like Receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants
VARIOUS RELATED VIRUSES (SARS-CoV, MERS, OTHER CORONAVIRUSES, ETC.)
September 2020
June 2020
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Structure of Coronavirus Main Proteinase Reveals Combination of a Chymotrypsin Fold with an Extra Α-Helical Domain - 6/23/2020
- Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease - 6/23/2020
May 2020
- Polyprotein Cleavage Mechanism of SARS CoV Mpro and Chemical Modification of the Octapeptide - 5/26/20
- Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1 - 5/26/20
- A Fusion Peptide in the Spike Protein of MERS Coronavirus (MERS peptide: RSARSAIEDLLFDKV, residues 884–898)
- Bat Coronavirus Phylogeography in the Western Indian Ocean
- Clues to COVID-19 Coronavirus’s Vulnerability Emerge From An Antibody Against SARS
- Prophylactic and Therapeutic Remdesivir (GS-5734) Treatment in the Rhesus Macaque Model of MERS-CoV Infection
- Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses