Many of the components of venoms and toxins are peptides. Some toxins contain the RGD-sequence (echistatin, for example), and others have a close similarity to human GLP-1 (exendin-4 is an incretin mimetic and GLP-1 agonist). As covered in several previous PepTalks, these peptides have many useful drug applications, including ion-channel blocking in pain therapeutics, antiplatelet activity, glioma cell binding, and diabetes. This week we present a handy guide of our readily available toxins, sorted by organism. New England Peptide / Peptides International carry several synthetic venoms and toxins, and their derivatives, from a variety of species. Check back periodically as the guide is a work in progress and details will continue to be added, along with new products. We can also custom synthesize a newly discovered or modified toxin to your specifications as well as create a heavy-labeled fragment for mass spectrometry analysis.
Bacteria
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| ENT-3981-PI |
Enterotoxin STh |
Enterotoxigenic E. coli
|
|
|
| ENT-3744-PI |
Enterotoxin STp |
Enterotoxigenic E. coli
|
|
|
| STX-001 |
Shiga Like Toxin-1 Subunit B Recombinant |
Escherichia coli verotoxin |
|
|
| STX-002 |
Shiga Like Toxin-2 Subunit B Recombinant |
Escherichia coli verotoxin |
|
|
| PRO-373 |
Listeriolysin-O Recombinant, PEST free |
Bacteria, Listeria monocytogenes |
|
|
| PRO-320 |
Listeriolysin-O Recombinant |
Bacteria, Listeria monocytogenes |
|
|
| |
|
|
|
|
Bee/Wasp
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| PAP-4257-v |
Apamin (0.5 mg vial) |
Honeybee, Apis mellifera
|
K+ (Ca2+-Activated ) |
SK-type |
| PMS-4107 |
Mastoparan |
Wasp, Vespula lewisii
|
|
|
| PMS-4107-v |
Mastoparan (0.5 mg vial) |
Wasp, Vespula lewisii
|
|
|
| PMC-4258-v |
MCD-Peptide (0.5 mg vial) |
Honeybee, Apis mellifera
|
K+ (Voltage-Dependent) |
| TOX-70001-P |
Melittin |
Honeybee, Apis mellifera
|
|
|
| ALR-001 |
Phospholipase A2 P00630 Bee Venom Protein Recombinant |
Honeybee, Apis mellifera
|
|
|
| PTK-4364-s |
Tertiapin (0.1mg vial) |
Honeybee, Apis mellifera
|
|
|
| TER-3833-PI |
Tertiapin Q |
Honeybee, Apis mellifera
|
|
|
Centipede
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| RHT-3832-PI |
RhTx |
Chinese red-headed centipede, Scolopendra subspinipes mutilans
|
|
|
Cone Snail
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| CON-3847-PI |
Tau Conotoxin CnVA |
Cone snail, Conus consors
|
|
|
| PCN-4126-v |
α-Conotoxin GI (0.5 mg vial) |
Marine Snail, Conus geographu
|
Other |
|
| PCN-4311-v |
α-Conotoxin ImI (0.5 mg vial) |
Marine Snail, Conus imperiali
|
|
|
| PCN-4140-v |
α-Conotoxin MI (0.5 mg vial) |
Marine Snail, Conus magus
|
|
|
| PCN-4228-v |
α-Conotoxin SI (0.5 mg vial) |
Marine Snail, Conus striatus
|
|
|
| PCN-4217-v |
μ-Conotoxin GIIIB (0.5 mg vial) |
Marine Snail, Conus geographu
|
Na+ |
|
| PCN-4263-v |
μ-Conotoxin GS (0.5 mg vial) |
Marine Snail, Conus geographu
|
Na+ |
|
| PCN-4440-v |
μ-Conotoxin SIIIA (0.5 mg vial) |
Marine Snail, Conus striatus
|
Na+ |
|
| PCN-4161-v |
ω-Conotoxin GVIA (0.5 mg vial) |
Marine Snail, Conus geographu
|
Ca2+ |
N-type |
| PCN-4289-v |
ω-Conotoxin MVIIA (0.5 mg vial); ziconotide |
Marine Snail, Conus magus
|
Ca2+ |
N-type |
| PCN-4283-s |
ω-Conotoxin MVIIC (0.1mg vial) |
Marine Snail, Conus magus
|
Ca2+ |
P/Q-type |
| PCN-4283-v |
ω-Conotoxin MVIIC (0.5 mg vial) |
Marine Snail, Conus magus
|
Ca2+ |
P/Q-type |
| PCN-4284-v |
ω-Conotoxin SVIB (0.5 mg vial) |
Marine Snail, Conus striatus
|
Ca2+ |
N-type |
Earthworm
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| NLY-14802-v |
Lysenin Antiserum (50 μl vial) |
earthworm, Eisenia foetida
|
|
|
Frog
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| PBM-4086 |
Bombesin |
Frog, Bombina bombina
|
|
|
| PBM-4086-v |
Bombesin (0.5 mg vial) |
Frog, Bombina bombina
|
|
|
Fungus
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| PCT-4494-v |
Candidalysin (0.5 mg vial) |
Fungus, Candida albicans
|
|
|
Gila Monster and Related Lizards
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| PEX-4345-v |
Exendin (5-39) (0.5 mg vial) |
Lizard, Heloderma horridum
|
|
|
| PEX-3784-PI |
Exendin-4 |
Lizard, Heloderma suspectum
|
|
|
| HOR-269 |
Exendin-4 (recombinant) |
Lizard, Heloderma suspectum
|
|
|
Scorpion
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| PCB-4227-s |
Charybdotoxin (0.1mg vial) |
Scorpion, Leiurus quinquestri
|
K+ (Ca2+-Activated ) |
IK-type |
| PCN-4282-v |
Chlorotoxin (0.5 mg vial) |
Scorpion, Leiurus quinquestri
|
Other |
|
| AA-016 |
HG1 Toxin |
Scorpion |
Specific for mKv1.3/KCNA3 Potassium Channel |
|
| THS-3822-PI |
HsTX1 |
Scorpion, Heterometrus spinnifer
|
|
|
| PIB-3813-PI |
Iberiotoxin |
Scorpion, Buthus tamulus
|
K+ (Ca2+-Activated ) |
BK-type |
| PIB-4235-s |
Iberiotoxin (0.1mg vial) |
Scorpion, Buthus tamulus
|
|
|
| PIM-4343-s |
Imperatoxin A (0.1mg vial) |
Scorpion, Pandinus imperator
|
|
|
| PKL-4259-s |
Kaliotoxin (1-37) (0.1mg vial) |
Scorpion, Androctonus maureta
|
K+ (Ca2+-Activated ) |
BK-type |
| PKT-4375-s |
Kurtoxin (0.1mg vial) |
Scorpion, Parabuthus transvaa
|
Ca2+ |
T-type |
| PAR-4290-s |
Margatoxin (0.1mg vial) |
Scorpion, Centruroides margar
|
K+ (Voltage-Dependent) |
| MAR-3811-PI |
Martentoxin I |
Scorpion, Buthus martensi
|
|
|
| ODT-3866-PI |
OD1 Toxin |
Scorpion, Odonthobuthus doriae
|
|
|
| PSC-4260-s |
Scyllatoxin (0.1mg vial) |
Scorpion, Leiurus quinquestri
|
K+ (Ca2+-Activated ) |
SK-type |
| PTT-4313-s |
Tityustoxin Kα (0.1mg vial) |
Scorpion, Tityus serrulatus
|
K+ (Voltage-Dependent) |
Sea Anemone
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| SHK-3746-PI |
5-Fam-ShK |
Sea Anemone, Stichodactyla helianthus
|
K+ (Voltage-Dependent) |
| APE-4472-s |
APETx2 (0.1 mg vial) |
Sea Anemone, Anthopleura elegantissima
|
Other |
|
| PSK-4287-s |
Stichodactyla Toxin (0.1mg vial) |
Sea Anemone, Stichodactyla helianthus
|
K+ (Voltage-Dependent) |
| SHK-3770-PI |
Stichodactyla Toxin Amide (ShK-amide) |
Sea Anemone, Stichodactyla helianthus
|
|
|
Snake
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| PRO-2146 |
Batroxobin (native) |
Snake, Bothrops atrox
|
|
|
| various |
Bradykinin and derivatives |
Pit viper, Bothrops jararaca
|
|
|
| PCC-4310-s |
Calcicludine (0.1mg vial) |
Green Mamba, Dendroaspis angusticeps
|
Ca2+ |
L-type |
| PCL-4255-s |
Calciseptine (0.1mg vial) |
Black mamba, Dendroaspis polylepis
|
Ca2+ |
L-type |
| PDN-4330-s |
Dendrotoxin I (0.1mg vial) |
Green Mamba, Dendroaspis angusticeps
|
K+ (Voltage-Dependent) |
| ECT-3760-PI |
Echistatin |
Snake, Echis carinatus
|
|
|
| EPT-3786-PI |
Eptifibatide |
Southeastern Pygmy Rattlesnake, Sistrurus miliarius barbouri
|
|
|
| MAM-3778-PI |
Mambalgin-1 |
Black mamba, Dendroaspis polylepis
|
Other |
|
| MAM-4473-s |
Mambalgin-1 (0.1mg vial) |
Black mamba, Dendroaspis polylepis
|
Other |
|
| PMT-4341-s |
Muscarinic Toxin 1 (0.1mg vial) |
Green Mamba, Dendroaspis angusticeps
|
|
|
| PMT-4410-s |
Muscarinic Toxin 3 (0.1mg vial) |
Green Mamba, Dendroaspis angusticeps
|
|
|
| PMT-4340-s |
Muscarinic Toxin 7 (0.1mg vial) |
Green Mamba, Dendroaspis angusticeps
|
|
|
| PMT-4424-s |
Muscarinic Toxin α (0.1mg vial) |
Black mamba, Dendroaspis polylepis
|
|
|
| PSF-4206-s |
Sarafotoxin S6b (0.1mg vial) |
Snake, Atractaspis engaddensi
|
|
|
| PSF-4246-s |
Sarafotoxin S6c (0.1mg vial) |
Snake, Atractaspis engaddensi
|
|
|
Spider
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| PAG-3402-s |
Biotinyl-ω-Agatoxin IVA (0.1mg vial) |
Funnel Web Spider, Agelenopsis aperta
|
|
|
| GOM-3848-PI |
Gomesin (AgGom) |
South American mygalomorph spider, Acanthoscurria gomesiana
|
|
|
| TGX-3862-PI |
GpTX-1 Toxin |
Tarantula, Grammostola porter
|
NaV1.7 |
|
| PCB-4393-s |
GsMTx-4 (0.1mg vial) |
Chilean Rose Tarantula, Grammostola spatulata
|
NaV2.1 |
|
| PGX-4433-s |
Guangxitoxin-1E (0.1mg vial) |
Tarantula, Plesiophrictus guangxiensis
|
K+ (Voltage-Dependent) |
| GOM-3849-PI |
HiGom |
Australian Funnel-Web Spider, Hadronyche infensa
|
|
|
| PCB-4455-s |
Huwentoxin-IV (0.1mg vial) |
Chinese Bird Spider, Ornithoctonus huwena
|
Na+
|
|
| TOX-3513-PI |
JzTx-V Peptide ; β/κ-theraphotoxin-Cg2a |
Chinese earth tiger tarantula, Chilobrachys jingzhao
|
|
|
| PLT-3409-v |
L17E Cytosolic Delivery Peptide (0.5 mg vial) |
Carolina wolf spider, Hogna carolinensis
|
|
|
| PNT-4195-s |
Neurotoxin NSTX-3 (0.1mg vial) |
Papua New Guinean Spider, Nephila maculata
|
|
|
| PPL-4300-s |
PLTX-II (0.1mg vial) |
Spider, Plectreurys tristes
|
Ca2+ |
T-type |
| PTX-4409-s |
ProTx-I (0.1mg vial) |
Tarantula, Thrixopelma pruriens
|
|
|
| PTX-3995-PI |
ProTx-II |
Tarantula, Thrixopelma pruriens
|
Na+ |
|
| PTX-4450-s |
ProTx-II (0.1mg vial) |
Tarantula, Thrixopelma pruriens
|
Na+ |
|
| PTX-4435-s |
Psalmotoxin 1 (0.1mg vial) |
South American Tarantula, Psalmopoeus cambridgei
|
|
|
| PPT-4457-s |
Purotoxin- 1 (0.1 mg vial) |
Wolf Spider, Geolycosa sp.
|
|
|
| PCB-4363-s |
SNX-482 (0.1mg vial) |
Tarantula, Hysterocrates giga
|
Ca2+ |
Class E (R-type) |
| TOX-3049-PI |
Tarantula Venom-Derived JzTx-V Peptide Analog |
Chinese earth tiger tarantula, Chilobrachys jingzhao
|
|
|
| PAG-4294-s |
ω -Agatoxin TK (0.1mg vial) |
Funnel Web Spider, Agelenopsis aperta
|
Ca2+ |
P-type |
| PAG-4256-s |
ω-Agatoxin IVA (0.1mg vial) |
Funnel Web Spider, Agelenopsis aperta
|
Ca2+ |
P-type |
Various
| Catalog Number |
Description |
Species |
Channel Blocked |
Channel Type |
| DML-8000 |
δ-melusine™ - Collection I |
Various |
|
|
