Many of the components of venoms and toxins are peptides. Some toxins contain the RGD-sequence (echistatin, for example), and others have a close similarity to human GLP-1 (exendin-4 is an incretin mimetic and GLP-1 agonist). As covered in several previous PepTalks, these peptides have many useful drug applications, including ion-channel blocking in pain therapeutics, antiplatelet activity, glioma cell binding, and diabetes. This week we present a handy guide of our readily available toxins, sorted by organism. New England Peptide / Peptides International carry several synthetic venoms and toxins, and their derivatives, from a variety of species. Check back periodically as the guide is a work in progress and details will continue to be added, along with new products. We can also custom synthesize a newly discovered or modified toxin to your specifications as well as create a heavy-labeled fragment for mass spectrometry analysis.
| Bacteria | Bee/Wasp | Centipede | Cone Snail |
| Earthworm | Frog | Fungus | Gila Monster/Lizards |
| Scorpion | Sea Anemone | Snake | Spider |
| Various |
|
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| ENT-3981-PI | Enterotoxin STh | Enterotoxigenic E. coli | ||
| ENT-3744-PI | Enterotoxin STp | Enterotoxigenic E. coli | ||
| STX-001 | Shiga Like Toxin-1 Subunit B Recombinant | Escherichia coli verotoxin | ||
| STX-002 | Shiga Like Toxin-2 Subunit B Recombinant | Escherichia coli verotoxin | ||
| PRO-373 | Listeriolysin-O Recombinant, PEST free | Bacteria, Listeria monocytogenes | ||
| PRO-320 | Listeriolysin-O Recombinant | Bacteria, Listeria monocytogenes | ||
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| PAP-4257-v | Apamin (0.5 mg vial) | Honeybee, Apis mellifera | K+ (Ca2+-Activated ) | SK-type |
| PMS-4107 | Mastoparan | Wasp, Vespula lewisii | ||
| PMS-4107-v | Mastoparan (0.5 mg vial) | Wasp, Vespula lewisii | ||
| PMC-4258-v | MCD-Peptide (0.5 mg vial) | Honeybee, Apis mellifera | K+ (Voltage-Dependent) | |
| TOX-70001-P | Melittin | Honeybee, Apis mellifera | ||
| ALR-001 | Phospholipase A2 P00630 Bee Venom Protein Recombinant | Honeybee, Apis mellifera | ||
| PTK-4364-s | Tertiapin (0.1mg vial) | Honeybee, Apis mellifera | ||
| TER-3833-PI | Tertiapin Q | Honeybee, Apis mellifera | ||
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| RHT-3832-PI | RhTx | Chinese red-headed centipede, Scolopendra subspinipes mutilans |
Cone Snail
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| CON-3847-PI | Tau Conotoxin CnVA | Cone snail, Conus consors | ||
| PCN-4126-v | α-Conotoxin GI (0.5 mg vial) | Marine Snail, Conus geographu | Other | |
| PCN-4311-v | α-Conotoxin ImI (0.5 mg vial) | Marine Snail, Conus imperiali | ||
| PCN-4140-v | α-Conotoxin MI (0.5 mg vial) | Marine Snail, Conus magus | ||
| PCN-4228-v | α-Conotoxin SI (0.5 mg vial) | Marine Snail, Conus striatus | ||
| PCN-4217-v | μ-Conotoxin GIIIB (0.5 mg vial) | Marine Snail, Conus geographu | Na+ | |
| PCN-4263-v | μ-Conotoxin GS (0.5 mg vial) | Marine Snail, Conus geographu | Na+ | |
| PCN-4440-v | μ-Conotoxin SIIIA (0.5 mg vial) | Marine Snail, Conus striatus | Na+ | |
| PCN-4161-v | ω-Conotoxin GVIA (0.5 mg vial) | Marine Snail, Conus geographu | Ca2+ | N-type |
| PCN-4289-v | ω-Conotoxin MVIIA (0.5 mg vial); ziconotide | Marine Snail, Conus magus | Ca2+ | N-type |
| PCN-4283-s | ω-Conotoxin MVIIC (0.1mg vial) | Marine Snail, Conus magus | Ca2+ | P/Q-type |
| PCN-4283-v | ω-Conotoxin MVIIC (0.5 mg vial) | Marine Snail, Conus magus | Ca2+ | P/Q-type |
| PCN-4284-v | ω-Conotoxin SVIB (0.5 mg vial) | Marine Snail, Conus striatus | Ca2+ | N-type |
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| NLY-14802-v | Lysenin Antiserum (50 μl vial) | earthworm, Eisenia foetida |
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| PBM-4086 | Bombesin | Frog, Bombina bombina | ||
| PBM-4086-v | Bombesin (0.5 mg vial) | Frog, Bombina bombina |
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| PCT-4494-v | Candidalysin (0.5 mg vial) | Fungus, Candida albicans |
Gila Monster and Related Lizards
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| PEX-4345-v | Exendin (5-39) (0.5 mg vial) | Lizard, Heloderma horridum | ||
| PEX-3784-PI | Exendin-4 | Lizard, Heloderma suspectum | ||
| HOR-269 | Exendin-4 (recombinant) | Lizard, Heloderma suspectum |
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| PCB-4227-s | Charybdotoxin (0.1mg vial) | Scorpion, Leiurus quinquestri | K+ (Ca2+-Activated ) | IK-type |
| PCN-4282-v | Chlorotoxin (0.5 mg vial) | Scorpion, Leiurus quinquestri | Other | |
| AA-016 | HG1 Toxin | Scorpion | Specific for mKv1.3/KCNA3 Potassium Channel | |
| THS-3822-PI | HsTX1 | Scorpion, Heterometrus spinnifer | ||
| PIB-3813-PI | Iberiotoxin | Scorpion, Buthus tamulus | K+ (Ca2+-Activated ) | BK-type |
| PIB-4235-s | Iberiotoxin (0.1mg vial) | Scorpion, Buthus tamulus | ||
| PIM-4343-s | Imperatoxin A (0.1mg vial) | Scorpion, Pandinus imperator | ||
| PKL-4259-s | Kaliotoxin (1-37) (0.1mg vial) | Scorpion, Androctonus maureta | K+ (Ca2+-Activated ) | BK-type |
| PKT-4375-s | Kurtoxin (0.1mg vial) | Scorpion, Parabuthus transvaa | Ca2+ | T-type |
| PAR-4290-s | Margatoxin (0.1mg vial) | Scorpion, Centruroides margar | K+ (Voltage-Dependent) | |
| MAR-3811-PI | Martentoxin I | Scorpion, Buthus martensi | ||
| ODT-3866-PI | OD1 Toxin | Scorpion, Odonthobuthus doriae | ||
| PSC-4260-s | Scyllatoxin (0.1mg vial) | Scorpion, Leiurus quinquestri | K+ (Ca2+-Activated ) | SK-type |
| PTT-4313-s | Tityustoxin Kα (0.1mg vial) | Scorpion, Tityus serrulatus | K+ (Voltage-Dependent) | |
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| SHK-3746-PI | 5-Fam-ShK | Sea Anemone, Stichodactyla helianthus | K+ (Voltage-Dependent) | |
| APE-4472-s | APETx2 (0.1 mg vial) | Sea Anemone, Anthopleura elegantissima | Other | |
| PSK-4287-s | Stichodactyla Toxin (0.1mg vial) | Sea Anemone, Stichodactyla helianthus | K+ (Voltage-Dependent) | |
| SHK-3770-PI | Stichodactyla Toxin Amide (ShK-amide) | Sea Anemone, Stichodactyla helianthus | ||
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| PRO-2146 | Batroxobin (native) | Snake, Bothrops atrox | ||
| various | Bradykinin and derivatives | Pit viper, Bothrops jararaca | ||
| PCC-4310-s | Calcicludine (0.1mg vial) | Green Mamba, Dendroaspis angusticeps | Ca2+ | L-type |
| PCL-4255-s | Calciseptine (0.1mg vial) | Black mamba, Dendroaspis polylepis | Ca2+ | L-type |
| PDN-4330-s | Dendrotoxin I (0.1mg vial) | Green Mamba, Dendroaspis angusticeps | K+ (Voltage-Dependent) | |
| ECT-3760-PI | Echistatin | Snake, Echis carinatus | ||
| EPT-3786-PI | Eptifibatide | Southeastern Pygmy Rattlesnake, Sistrurus miliarius barbouri | ||
| MAM-3778-PI | Mambalgin-1 | Black mamba, Dendroaspis polylepis | Other | |
| MAM-4473-s | Mambalgin-1 (0.1mg vial) | Black mamba, Dendroaspis polylepis | Other | |
| PMT-4341-s | Muscarinic Toxin 1 (0.1mg vial) | Green Mamba, Dendroaspis angusticeps | ||
| PMT-4410-s | Muscarinic Toxin 3 (0.1mg vial) | Green Mamba, Dendroaspis angusticeps | ||
| PMT-4340-s | Muscarinic Toxin 7 (0.1mg vial) | Green Mamba, Dendroaspis angusticeps | ||
| PMT-4424-s | Muscarinic Toxin α (0.1mg vial) | Black mamba, Dendroaspis polylepis | ||
| PSF-4206-s | Sarafotoxin S6b (0.1mg vial) | Snake, Atractaspis engaddensi | ||
| PSF-4246-s | Sarafotoxin S6c (0.1mg vial) | Snake, Atractaspis engaddensi | ||
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| PAG-3402-s | Biotinyl-ω-Agatoxin IVA (0.1mg vial) | Funnel Web Spider, Agelenopsis aperta | ||
| GOM-3848-PI | Gomesin (AgGom) | South American mygalomorph spider, Acanthoscurria gomesiana | ||
| TGX-3862-PI | GpTX-1 Toxin | Tarantula, Grammostola porter | NaV1.7 | |
| PCB-4393-s | GsMTx-4 (0.1mg vial) | Chilean Rose Tarantula, Grammostola spatulata | NaV2.1 | |
| PGX-4433-s | Guangxitoxin-1E (0.1mg vial) | Tarantula, Plesiophrictus guangxiensis | K+ (Voltage-Dependent) | |
| GOM-3849-PI | HiGom | Australian Funnel-Web Spider, Hadronyche infensa | ||
| PCB-4455-s | Huwentoxin-IV (0.1mg vial) | Chinese Bird Spider, Ornithoctonus huwena | Na+ | |
| TOX-3513-PI | JzTx-V Peptide ; β/κ-theraphotoxin-Cg2a | Chinese earth tiger tarantula, Chilobrachys jingzhao | ||
| PLT-3409-v | L17E Cytosolic Delivery Peptide (0.5 mg vial) | Carolina wolf spider, Hogna carolinensis | ||
| PNT-4195-s | Neurotoxin NSTX-3 (0.1mg vial) | Papua New Guinean Spider, Nephila maculata | ||
| PPL-4300-s | PLTX-II (0.1mg vial) | Spider, Plectreurys tristes | Ca2+ | T-type |
| PTX-4409-s | ProTx-I (0.1mg vial) | Tarantula, Thrixopelma pruriens | ||
| PTX-3995-PI | ProTx-II | Tarantula, Thrixopelma pruriens | Na+ | |
| PTX-4450-s | ProTx-II (0.1mg vial) | Tarantula, Thrixopelma pruriens | Na+ | |
| PTX-4435-s | Psalmotoxin 1 (0.1mg vial) | South American Tarantula, Psalmopoeus cambridgei | ||
| PPT-4457-s | Purotoxin- 1 (0.1 mg vial) | Wolf Spider, Geolycosa sp. | ||
| PCB-4363-s | SNX-482 (0.1mg vial) | Tarantula, Hysterocrates giga | Ca2+ | Class E (R-type) |
| TOX-3049-PI | Tarantula Venom-Derived JzTx-V Peptide Analog | Chinese earth tiger tarantula, Chilobrachys jingzhao | ||
| PAG-4294-s | ω -Agatoxin TK (0.1mg vial) | Funnel Web Spider, Agelenopsis aperta | Ca2+ | P-type |
| PAG-4256-s | ω-Agatoxin IVA (0.1mg vial) | Funnel Web Spider, Agelenopsis aperta | Ca2+ | P-type |
| Catalog Number | Description | Species | Channel Blocked | Channel Type |
| DML-8000 | δ-melusine™ - Collection I | Various |