Product Name: Rapamycin

Product Number: IRA-3884-PI

Synonym(s): Sirolimus; AY-22989; WY-090217; NSC-226080; Rapamune

Application: mTOR Inhibitor

Description: Rapamycin is a clinically useful immunosuppressant that inhibits the response to interleukin-2 blocking activation of T- and B-cells and induces autophagy. Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that binds to mTOR Complex1 (mTORC1), inhibiting the mammalian target of rapamycin (mTOR). It can also bind to mTORC2, leading to decreased glucose tolerance and insensitivity to insulin. Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

CAS Number: 53123-88-9

Molecular Weight (g/mol): 914.17

Purity: 98% NMR (Conforms)

Storage Conditions: -20 °C

Reference(s): Kay, et al., Immunology, 72, 544 (1991). Mita, et al., Cancer Biol. Ther., 2(4 Suppl 1), S169 (2003). Lamming, et al., Science, 335, 1638 ( 2012). Sarkar, et al., Cell Death and Differentiation, 16, 46 (2009). A Flemming, et al., Nat. Chem. Biol., 11, 7 (2011).

Special Note(s): For research use ONLY. Not for use on humans.