omega-Conotoxin GVIA (0.5 mg vial)
Product Name: omega-Conotoxin GVIA (0.5 mg vial)
Product Number: PCN-4161-v
Synonym(s): Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2
Disulfide Bonds: (Disulfide bonds between Cys1-Cys16, Cys8-Cys19, and Cys15-Cys26)
Application: N-type Ca2+ Channel Blocker
Description: A synthetic cone snail toxin
Source: (Marine Snail, Conus geographus)
CAS Number: 106375-28-4
Molecular Weight (g/mol): 3037.3
Storage Conditions: 2-10 °C
Reference(s): B.M. Olivera, J.M. McIntosh, L.J. Cruz, F.A. Luque, and W.R. Gray, Biochemistry, 23, 5087 (1984). (Original) Y. Nishiuchi, K.Y. Kumagaye, Y. Noda, T.X. Watanabe, and S. Sakakibara, Biopolymers, 25, S61 (1986). (Chem. Synthesis & S-S Bond) B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review) W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review) R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review) ; B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)
Special Note(s): For research use ONLY. Not for use on humans.