omega-Conotoxin GVIA (0.5 mg vial)

Product Name: omega-Conotoxin GVIA (0.5 mg vial)

Product Number: PCN-4161-v

Synonym(s): Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2

Disulfide Bonds: (Disulfide bonds between Cys1-Cys16, Cys8-Cys19, and Cys15-Cys26)

Application: N-type Ca2+ Channel Blocker

Description: A synthetic cone snail toxin

Source: (Marine Snail, Conus geographus)

CAS Number: 106375-28-4

Molecular Weight (g/mol): 3037.3

Storage Conditions: 2-10 °C

Reference(s): B.M. Olivera, J.M. McIntosh, L.J. Cruz, F.A. Luque, and W.R. Gray, Biochemistry, 23, 5087 (1984). (Original) Y. Nishiuchi, K.Y. Kumagaye, Y. Noda, T.X. Watanabe, and S. Sakakibara, Biopolymers, 25, S61 (1986). (Chem. Synthesis & S-S Bond) B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review) W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review) R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review) ; B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)

Special Note(s): For research use ONLY. Not for use on humans.