Mu-Conotoxin GIIIB (0.5 mg vial)
Product Name: Mu-Conotoxin GIIIB (0.5 mg vial)
Product Number: PCN-4217-v
Synonym(s): Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2
Disulfide Bonds: (Disulfide bonds between Cys3-Cys15, Cys4-Cys20, and Cys10-Cys21)
Application: Na+ Channel Blocker: Specific for Skeletal Muscle
Description: A synthetic cone snail toxin
Source: (Marine Snail, Conus geographus)
Molecular Weight (g/mol): 2640.2
Storage Conditions: 2-10 °C
Reference(s): S. Sato, H. Nakamura, Y. Ohizumi, J. Kobayashi, and Y. Hirata, FEBS Lett., 155, 277 (1983). (Original) L.J. Cruz, W.R. Gray, B.M. Olivera, R.D. Zeikus, L. Kerr, D. Yoshikami, and E. Moczydlowski, J. Biol. Chem., 260, 9280 (1985). (Naming) Y. Ohizumi, H. Nakamura, J. Kobayashi, and W.A. Catterall, J. Biol. Chem., 261, 6149 (1986). (Pharmacol.) S. Kubo, N. Chino, T.X. Watanabe, T. Kimura, and S. Sakakibara, Pept. Res., 6, 66 (1993). (Chem. Synthesis & Pharmacol.) B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review) W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review) R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review) B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review) B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)
Special Note(s): For research use ONLY. Not for use on humans.