Kurtoxin (0.1mg vial)

Product Name: Kurtoxin (0.1mg vial)

Product Number: PKT-4375-s

Synonym(s): Lys-Ile-Asp-Gly-Tyr-Pro-Val-Asp-Tyr-Trp-Asn-Cys-Lys-Arg-Ile-Cys-Trp-Tyr-Asn-Asn-Lys-Tyr-Cys-Asn-Asp-Leu-Cys-Lys-Gly-Leu-Lys-Ala-Asp-Ser-Gly-Tyr-Cys-Trp-Gly-Trp-Thr-Leu-Ser-Cys-Tyr-Cys-Gln-Gly-Leu-Pro-Asp-Asn-Ala-Arg-Ile-Lys-Arg-Ser-Gly-Arg-Cys-Arg-Ala

Disulfide Bonds: (Disulfide bonds between Cys12-Cys61Cys16-Cys37, Cys23-Cys44, and Cys27-Cys46)

Application: T-type Ca2+ Channel Blocker

Description: synthetic scorpion toxin

Source: (Scorpion, Parabuthus transvaalicus)

Molecular Weight (g/mol): 7386.4

Storage Conditions: -20 °C

Reference(s): R.S-I. Chuang, H. Jaffe, L. Cribbs, E. Perez-Reyes, and K.J. Swartz, Nat. Neurosci., 1, 668 (1998). (Original) S.S. Sidach and I.M. Mintz, J. Neurosci., 22, 2023 (2002). (Pharmacol.; Specificity for Ca<sup>2+</sup> Channel Blocking Activity) T. Olamendi-Portugal, B.I. Garcá, I. López-González, J. Van Der Walt, K. Dyason, C. Ulens, J. Tytgat, R. Felix, A. Darszon, and L.D. Possani, Biochem. Biophys. Res. Commun., 299, 562 (2002). (Pharmacol.) I. López-González, T. Olamendi-Portugal, J.L. De La Vega-Beltrán, J. Van der Walt, K. Dyason, L.D. Possani, R. Felix, and A. Darszon, Biochem. Biophys. Res. Commun., 300, 408 (2003). (Pharmacol.) H. Nishio, Y. Nishiuchi, M. Ishimaru, and T. Kimura, Lett. Pept. Sci., in press. (Chem. Synthesis & S-S Bond)

Special Note(s): For research use ONLY. Not for use on humans.