IFN b 1a Human

Product Name: IFN b 1a Human

Product No: CYT-236

Synonym(s): IFN-Beta 1a Human Recombinant, Leukocyte IFN, B cell IFN, Type I IFN, IFNB1, IFB, IFF, IFNB, IFN-b 1a ,MGC96956.

Description: IFN-beta 1a Human Recombinant produced in CHO (Chinese Hamster Ovarian) cells is a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 22500 Dalton.IFN-beta1a is purified by proprietary chromatographic techniques.

Protein Derived From: CHO (Chinese Hamster Ovarian) cells.

Purity: Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Stability: Lyophilized IFN-beta 1a although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IFN-Beta1a should be stored at 4C between 2-7 days and for future use below -18C.Please prevent freeze-thaw cycles.

Biological Activity: The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 270 x 106 IU/mg.

Solubility: It is recommended to reconstitute the lyophilized IFN beta 1a in sterile 18MOmegacm H2O not less than 100microg/ml, which can then be further diluted to other aqueous solutions.

References: Title:IFNG induces apoptosis in human SH-SY5Y neuroblastoma cells through activation of JAK–STAT signaling and down-regulation of PI3K/Akt pathway.Publication:Article first published online: 11 NOV 2010 DOI:10.1111/j.1471-4159.2010.07046.xLink:http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2010.07046.x/full

Special Note(s): ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.