MAL-dPEG®8-Acid

Product Name: MAL-dPEG®8-Acid

Product Number: DPG-6218

Description: dPEG; Spacer is 34 atoms and 37.034 angstrom References:Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SMCC or sulfo-SMCC on pp. 283-286.Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG; products.Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. Arnaud C. Tiberghien, Jean-Noel Levy, Luke A. Masterson, Neki V. Patel, Lauren R. Adams, Simon Corbett, David G. Williams, John A. Hartley, and Philip W. Howard. ACS Medicinal Chemistry Letters. 2016, 7 (11), pp 983–987. May 24, 2016. DOI: 10.1021/acsmedchemlett.6b00062.Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer. Jason B. White, Ryan Fleming, Luke Masterson, Ben T. Ruddle, Haihong Zhong, Christine Fazenbaker, Patrick Strout, Kim Rosenthal, Molly Reed, Vanessa Muniz-Medina, Philip Howard, Rakesh Dixit, Herren Wu, Mary Jane Hinrichs, Changshou Gao & Nazzareno Dimasi. mAbs. 2019. March 5, 2019. DOI: 10.1080/19420862.2019.1578611

Source:

CAS Number: 1334177-86-4

Molecular Weight (g/mol): 592.63; single compound

Storage Conditions: -20 °C

Special Note(s): For research use ONLY. Not for use on humans.