LISA-101 (0.1mg vial)
Product Name: LISA-101 (0.1mg vial)
Product Number: GLU-3234-s
Synonym(s): gamma-l-Glutamyl-(2S)-gamma-ethyl-gamma-[(3-oxo-3H-phenoxazin-7-yl)oxy]carbonyl-2,4-diaminobutyric acid
Application: Fluorogenic Substrate for gamma-Glutamyl Cyclotransferase (GGCT)
Description: LISA-101 is a fluorogenic substrate for γ-Glutamyl Cyclotransferase (GGCT), which is upregulated in a wide range of cancers, including breast and prostate cancer.
Salt Form: Trifluoroacetate Salt
CAS Number: 1638785-74-6
Molecular Weight (g/mol): 514.48
Storage Conditions: -20 °C
Reference(s): M. Orlowski, P.G. Richman, and A. Meister,; Biochemistry,; 8, 1048 (1969).; (Isolation and Identification of GGCT) A.J. Oakley, T. Yamada, D. Liu, M. Coggan, A.G. Clark, and P.G. Board,; J. Biol. Chem.,; 283, 22031 (2008).; (Isolation and Identification of GGCT) P. Gromov, I. Gromova, E. Friis, V. Timmermans-Wielenga, F. Rank, R. Simon, G. Sauter, and J.M.A. Moreira,; J. Proteome Res.,; 9, 3941 (2010).; (Proteomic Profiling of Mammary Carcinomas) K. Takemura, H. Kawachi, Y. Eishi, K. Kitagaki, M. Negi, M. Kobayashi, K. Uchida, J. Inoue, J. Inazawa, T. Kawano, and P.G. Board,; Human Pathol.,; 45, 331 (2014).; (GGCT as a Diagnostic Marker in Esophageal Tumors) R. Ran, Y. Liu, H. Gao, Q. Kuang, Q. Zhang, J. Tang, H. Fu, Z. Zhang, and Q. He,; J. Pham. Sci.,; 104, 476 (2015).; (siRNA for Treatment of Drug-Resistant Breast Cancer) T. Yoshiya, H. Ii, S. Tsuda, S. Kageyama, T. Yoshiki and Y. Nishiuchi,; Org. Biomol. Chem., doi: 10.1039/C5OB00086F (2015). (Development of LISA-101);
Special Note(s): For research use ONLY. Not for use on humans.