Product Name: (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu

Product Number: IGS-3641-PI

Synonym(s): DAPT N-[N-(3,5-Difluorophenacetyl)-L-Alanyl)]-S-Phenylglycine t-Butyl Ester

Application: Inhibitor for gamma-Secretase

CAS Number: 208255-80-5

Molecular Weight (g/mol): 432.47

Storage Conditions: -20 °C

Reference(s): H.F. Dovey, V. John, J.P. Anderson, L.Z. Chen, P. de Saint. Andrieu, L.Y. Fang, S.B. Freedman, B. Folmer, E. Goldbach, E.J. Holsztynska, K.L. Hu, K.L. Johnson-Wood, S.L. Kennedy, D. Kholodenko, J.E. Knops, L.H. Latimer, M. Lee, Z. Liao, I.M. Lieberburg, R.N. Motter, L.C. Mutter, J. Nietz, K.P. Quinn, K.L. Sacchi, P.A. Seubert, G.M. Shopp, E.D. Thorsett, J.S. Tung, J. Wu, S. Yang, C.T. Yin, D.B. Schenk, P.C. May, L.D. Altstiel, M.H. Bender, L.N. Boggs, T.C. Britton, J.C. Clemens, D.L. Czilli, D.K. Dieckman-McGinty, J.J. Droste, K.S. Fuson, B.D. Gitter, P.A. Hyslop, E.M. Johnstone, W-Y. Li, S.P. Little, T.E. Mabry, F.D. Miller, B. Ni, J.S. Nissen, W.J. Porter, B.D. Potts, J.K. Reel, D. Stephenson, Y. Su, L.A. Shipley, C.A. Whitesitt, T. Yin, and J.E. Audia, J. Neurochem., 76, 173 (2001). (Original; Functional ?-Secretase Inhibitor in Brain) A.Y. Kornilova, C. Das, and M.S. Wolfe, J. Biol. Chem., 278, 16470 (2003). (Comparison of in Cells and Cell-Free Activity)

Special Note(s): For research use ONLY. Not for use on humans.