Camostat Mesilate

Product Name: Camostat Mesilate

Product Number: ISP-3606-PI

Synonym(s): 4-(2-(2-(Dimethylamino)-2-Oxoethoxy)-2-Oxoethyl)Phenyl 4-Guanidinobenzoate, Methanesulfonic Acid Salt; FOY-305; Foipan

Application: A Serine Protease Inhibitor; Shown to Inhibit Viral Entry Into Human Lung Cells

Description: Camostat mesilate is a serine protease inhibitor that inhibits plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis.; It reduces weight gain and improves metabolism in obese rodent models.; It is in clinical use (in Japan) for pancreatitis.; Camostat has been found to inhibit influenza virus replication in human tracheal epithelial cells and is also a direct prostasin inhibitor which may be useful in reducing sodium transport in cystic fibrosis. Additionally it has been shown to reduce infection of Calu-3 lung cells by SARS-CoV-2 (the coronavirus responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming. Find other coronavirus products and news here.

CAS Number: 59721-29-8

Molecular Weight (g/mol): 494.5

Purity: >98% (HPLC); NMR (Conforms)

Storage Conditions: -20 °C

Reference(s): J Gibo, et al., Lab. Invest., 85, 75 (2005). K Albarazanji, et al., Am. J. Physiol. Gastrointest. Liver Physiol., 316, G653 (2019). M Ueda, et al., Nephron, 129, 223 (2015). M Yamaya, et al., Pulm. Pharmacol. Ther., 33, 66 (2015). M Hoffmann, et al., Cell, 181, 1 (2020). S. M. Rowe, et al., Chest., 144(1), 200 (2013).

Special Note(s): For research use ONLY. Not for use on humans.