Product Name: PyBOP®
Product Number: KPC-1068-PI
Synonym(s): Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Application: Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product. Coupling reactions are rapid, being nearly complete within a few minutes. May be used in place of BOP in peptide synthesis without loss of coupling efficiency. Especially useful for cyclization steps for the activation of hindered amino acid.
CAS Number: 128625-52-5
Molecular Weight (g/mol): 520.39
Storage Conditions: 2-10 °C
Reference(s): J. Putura, P.M. Turunen, M.H. Jäntti, M.E. Ekholm, and J.P. Kukkonen, Neurosci. Lett., 494, 57 (2011). (Pharmacol.) ; J. Coste,; D. Le-Nguyen,; B. Castro, PyBOP;: A new peptide coupling reagent devoid of toxic by-product ; S. Asahi, S.-I. Egashira, M. Matsuda, H. Iwaasa, A. Kanatani, M. Ohkubo, M. Ihara, and H. Morishima, Bioorg. Med. Chem. Lett., 13, 111 (2003). (Original; Structure-Activity Relationship & Pharmacol.)
Special Note(s): For research use ONLY. Not for use on humans.