Product Name: OxymaPure®
Product Number: OXY-1050-PI
Synonym(s): Ethyl (Hydroxyimino)Cyanoacetate, Ethyl Cyano(Hydroxyimino)Acetate, Ethyl Cyanoglyoxalate-2-Oxime, Ethyl Isonitrosocyanoacetate, ethyl-2- Cyano-2-(Hydroxyimino)-Acetate
Application: Considered as a replacement for HOBt , HOAT , HOOBt, HOPO , Cl-HOBT and other analogues
Description: An ideal additive used with carbodiimide coupling methodology for amide bond formation. ; The 2-cyano-2-(hydroxyimino)acetate displays a remarkable capacity to suppress racemization and an impressive coupling efficiency in both automated and manual synthesis. OxymaPure; has a pKa=4.60 OxymaPure;; has been tested for oral toxicity and dermal irritation and was found as non-toxic and non-allergic (Safe (LD50 = 300-2000 mg/kg)). It also has less risk of explosively; and; flammability than similar products and has no limitation in land, sea and air transportation (low risk of explosion).
CAS Number: 3849-21-6
Molecular Weight (g/mol): 142.12
Storage Conditions: 2-10 °C
Reference(s): J.M. Collins, et al., Org. Lett., 16, 940 (2014). S.N. Khattab,; et al., Eur. J. Org. Chem., 3275 (2010). R. Subiros-Funosas,; et al., Chem. Eur. J., 15, 9394 (2009). N. Babu Palakurthy,; et al., Eur. J. Org. Chem., 2627 (2013). R.Subiros-Funosas,; et al.,; PeptideScience, 98, Vol. 2 S.N. Khattab, Bull. Chem. Soc. Jpn., 83, No. 11, 1374 (2010).
Special Note(s): For research use ONLY. Not for use on humans.