Omega-Agatoxin TK (0.1mg vial)

Product Name: Omega-Agatoxin TK (0.1mg vial)

Product Number: PAG-4294-s

Synonym(s): Omega-Agatoxin IVB; Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-D-Ser-Phe-Ala; omega-Aga-TK

Disulfide Bonds: (Disulfide bonds between Cys4-Cys20, Cys12-Cys25,Cys19-Cys36 and Cys27-Cys34)

Application: P-type Ca2+ Channel Selective Blocker

Description: A synthetic spider toxin

Source: (Funnel Web Spider, Agelenopsis aperta)

CAS Number: 145017-83-0

Molecular Weight (g/mol): 5273

Storage Conditions: -20 °C

Reference(s): M. Kuwada, T. Teramoto, K.Y. Kumagaye, K. Nakajima, T.Watanabe, T. Kawai, Y. Kawakami, T. Niidome, K. Sawada, Y. Nishizawa, and K. Katayama, Mol. Pharmacol., 46, 587 (1994). (Original) Y. Shikata, T. Watanabe, T. Teramoto, A. Inoue, Y. Kawakami, Y. Nishizawa, K. Katayama, and M. Kuwada, J. Biol. Chem., 270, 16719 (1995). (L-Ser to D-Ser Isomerase) T. Kozaki, M. Kuwada, M. Narukawa, Y. Nagai, and N. Asakawa, Peptide Chemistry 1995, 245 (1996). (Pharmacol.) T. Teramoto, T. Niidome, M. Kimura, M. Ohgoh, Y. Nishizawa, K. Katayama, T. Mayumi, and K. Sawada, Brain Res., 756, 225 (1997). (Pharmacol.) B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review) O.D. Uchitel, Toxicon, 35, 1161 (1997). (Review) M. E. Adams, I. M. Mintz, M. D. Reily, V. Thanabal, and B. P. Bean, Molecular Pharmacology, 44 (4), 681 (1993).

Special Note(s): For research use ONLY. Not for use on humans.