Margatoxin (0.1mg vial)

Product Name: Margatoxin (0.1mg vial)

Product Number: PAR-4290-s

Synonym(s): Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His

One-Letter-Code: H-TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH-OH

Disulfide Bonds: (Disulfide bonds between Cys7-Cys29, Cys13-Cys34, and Cys17-Cys36)

Application: Volgate-Dependent K+ Channel Blocker (Specific for Kv13 Channel)

Description: A synthetic scorpion toxin

Source: (Scorpion, Centruroides margaritatus)

CAS Number: 145808-47-5

Molecular Weight (g/mol): 4178.9

Storage Conditions: -20 °C

Reference(s): R.J. Leonard, M.L. Garcia, R.S. Slaughter, and J.P. Reuben, Proc. Natl. Acad. Sci. U.S.A., 89, 10094 (1992). (Pharmacol.) M. Garcia-Calvo, R.J. Leonard, J. Novick, S.P. Stevens, W. Schmalhofer, G.J. Kaczorowski, and M.L. Garcia, J. Biol. Chem., 268, 18866 (1993). (Original) M.A. Bednarek, R.M. Bugianesti, R.J. Leonard, and J.P. Felix, Biochem. Biophys. Res. Commun., 198, 619 (1994). (Chem. Synthesis & S-S Bond) H.G. Knaus, R.O.A. Koch, A. Eberhart, G.J. Kaczorowski, M.L. Garcia, and R.S. Slaughter, Biochemistry, 34,13627 (1995). (Pharmacol.)

Special Note(s): For research use ONLY. Not for use on humans.