Huwentoxin-IV (0.1mg vial)

Product Name: Huwentoxin-IV (0.1mg vial)

Product Number: PCB-4455-s

Synonym(s): HWTX-IV, Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Arg-Trp-Cys-Lys-Tyr-Gln-Ile-NH2

Disulfide Bonds: Disulfide bonds between Cys2- Cys17, Cys9- Cys24, and Cys16- Cys31

Application: Neuronal Tetrodotoxin-Sensitive Na+- Channel Blocker

Description: Sequence originally discovered from the venom of the Chinese bird spider, Selenocosmia huwena.

Source: Chinese Bird Spider, Ornithoctonus huwena

Salt Form: Trifluoroacetate Salt

Molecular Weight (g/mol): 4106.8

Storage Conditions: -20 °C

Reference(s): K. Peng, Q. Shu, Z. Liu, and S. Liang, J. Biol. Chem., 277, 47564 (2002). (Original) J. Diao, Y. Lin, J. Tang, and S. Liang, Toxicon, 42, 715 (2003). (cDNA Seq) Y. Xiao, J.-P. Bingham, W. Zhu, E. Moczydlowski, S. Liang, and T.R. Cummins, J. Biol. Chem., 283, 27300 (2008). (Pharmacol.) Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, X. Zeng, and S. Liang, Toxicon, 51, 230 (2008). (Pharmacol.) A.J. Agwa, P. Tran, A. Mueller, H.N.T. Tran, J.R. Deuis, M.R. Israel, K.L. McMahon, D.J. Craik, I. Vetter, and C.I. Schroeder, Journ. Cell Bio. (2020). doi: 10.1074/jbc.RA119.012281 jbc.RA119.012281

Special Note(s): For research use ONLY. Not for use on humans.