Huwentoxin-IV (0.1mg vial)
Product Name: Huwentoxin-IV (0.1mg vial)
Product Number: PCB-4455-s
Synonym(s): HWTX-IV, Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Arg-Trp-Cys-Lys-Tyr-Gln-Ile-NH2
Disulfide Bonds: Disulfide bonds between Cys2- Cys17, Cys9- Cys24, and Cys16- Cys31
Application: Neuronal Tetrodotoxin-Sensitive Na+- Channel Blocker
Description: Sequence originally discovered from the venom of the Chinese bird spider, Selenocosmia huwena.
Source: Chinese Bird Spider, Ornithoctonus huwena
Salt Form: Trifluoroacetate Salt
Molecular Weight (g/mol): 4106.8
Storage Conditions: -20 °C
Reference(s): K. Peng, Q. Shu, Z. Liu, and S. Liang, J. Biol. Chem., 277, 47564 (2002). (Original) J. Diao, Y. Lin, J. Tang, and S. Liang, Toxicon, 42, 715 (2003). (cDNA Seq) Y. Xiao, J.-P. Bingham, W. Zhu, E. Moczydlowski, S. Liang, and T.R. Cummins, J. Biol. Chem., 283, 27300 (2008). (Pharmacol.) Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, X. Zeng, and S. Liang, Toxicon, 51, 230 (2008). (Pharmacol.) A.J. Agwa, P. Tran, A. Mueller, H.N.T. Tran, J.R. Deuis, M.R. Israel, K.L. McMahon, D.J. Craik, I. Vetter, and C.I. Schroeder, Journ. Cell Bio. (2020). doi: 10.1074/jbc.RA119.012281 jbc.RA119.012281
Special Note(s): For research use ONLY. Not for use on humans.