Mu-Conotoxin GIIIB (0.5 mg vial)

Product Name: Mu-Conotoxin GIIIB (0.5 mg vial)

Product Number: PCN-4217-v

Synonym(s): Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2

Disulfide Bonds: (Disulfide bonds between Cys3-Cys15, Cys4-Cys20, and Cys10-Cys21)

Application: Na+ Channel Blocker: Specific for Skeletal Muscle

Description: A synthetic cone snail toxin

Source: (Marine Snail, Conus geographus)

Molecular Weight (g/mol): 2640.2

Storage Conditions: 2-10 °C

Reference(s): S. Sato, H. Nakamura, Y. Ohizumi, J. Kobayashi, and Y. Hirata, FEBS Lett., 155, 277 (1983). (Original) L.J. Cruz, W.R. Gray, B.M. Olivera, R.D. Zeikus, L. Kerr, D. Yoshikami, and E. Moczydlowski, J. Biol. Chem., 260, 9280 (1985). (Naming) Y. Ohizumi, H. Nakamura, J. Kobayashi, and W.A. Catterall, J. Biol. Chem., 261, 6149 (1986). (Pharmacol.) S. Kubo, N. Chino, T.X. Watanabe, T. Kimura, and S. Sakakibara, Pept. Res., 6, 66 (1993). (Chem. Synthesis & Pharmacol.) B.M. Olivera,W.R. Gray, R. Zeikus, J.M. McIntosh, J. Varga, J. Rivier, V. De Santos, and L.J. Cruz, Science, 230, 1338 (1985). (Review) W.R. Gray, B.M. Olivera, and L.J. Cruz, Annu. Rev. Biochem., 57, 665 (1988). (Review) R.A. Myers, L.J. Cruz, J.E. Rivier, and B.M. Olivera, Chem. Rev., 93, 1923 (1993). (Review) B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review) B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review)

Special Note(s): For research use ONLY. Not for use on humans.