alpha-Defensin-5 (Human) (0.1mg vial)

Product Name: alpha-Defensin-5 (Human) (0.1mg vial)

Product Number: PDF-4415-s

Synonym(s): Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-Cys-Ala-Thr-Arg-Glu-Ser-Leu-Ser-Gly-Val-Cys-Glu-Ile-Ser-Gly-Arg-Leu-Tyr-Arg-Leu-Cys-Cys-Arg, HD-5, Human Defensin-5, alpha-Defensin-5, DEFA5

One-Letter-Code: H-ATCYCRTGRCATRESLSGVCEISGRLYRLCCR-OH

Disulfide Bonds: (Disulfide bonds between Cys3-Cys31, Cys5-Cys20, and Cys10-Cys30)

Application: Antimicrobial Peptide in Paneth Cells

Molecular Weight (g/mol): 3582.1

Storage Conditions: -20 °C

Reference(s): T. Ganz, M.E. Selsted, D. Szklarek, S.S.L. Harwig, K. Daher, D.F. Bainton, and R.I. Lehrer, J. Clin. Invest., 76, 1427 (1985). (Original; Isolation of HNP 1-3); M.E. Selsted, S.S.L. Harwig, T. Ganz, J.W. Schilling, and R.I. Lehrer, J. Clin. Invest., 76, 1436 (1985). (Original; Structure of HNP 1-3); X.-M. Fang, Q. Shu, Q.-X. Chen, M. Book, H.-G. Sahl, A. Hoeft, and F. Stuber, Eur. J. Clin. Invest., 33, 82 (2003). (Histochem.; Regulation of Expression); R.I. Lehrer and T. Ganz, Ann. N.Y. Acad. Sci., 797, 228 (1996). (Review) E. Martin Porter, M.A. Poles, J.S. Lee, J. Naitoh, C.L. Bevins, amd T. Ganz, FEBS Lett., 434, 272 (1998). (Endogenous Form); N.H. Salzman, D. Ghosh, K.M. Huttner, Y. Paterson, and C.L. Bevins, Nature, 422, 522 (2003). (Pharmacol.); P. Kelly, R. Feakins, P. Domizio, J. Murphy, C. Bevins, J. Wilson, G. Mcphail, R. Poulsom, and W. Dhaliwal, Clin. Exp. Immunol., 135, 303 (2004). (Histochem.; Location in AIDS Patients) F.T. Lundy, D.F. Orr, J.R. Gallagher, P. Maxwell, C. Shaw, S.S. Napier, C.G. Cowan, P.-J. Lamey, and J.J. Marley, Oral Oncol., 40, 139 (2004). (Pharmacol.; Role in Tumor Invasion) L. Zhang, W. Yu, T. He, J. Yu, R.E. Caffrey, E.A. Dalmasso, S. Fu, T. Pham, J. Mei, J.J. Ho, W. Zhang, P. Lopez, and D.D. Ho, Science, 298, 995 (2002)(Pharmacol.; Anti-HIV-1 Activity) R.N. Cunliffe, Mol. Immunol., 40, 463 (2003). (Histochem.; a-Defensin in Gastrointestinal Tract) D.E. Jones and C.L. Bevins, J. Biol. Chem., 267, 23216 (1992). (Original)

Special Note(s): For research use ONLY. Not for use on humans.