Cryptdin-4 (Mouse) (0.1 mg vial)

Product Name: Cryptdin-4 (Mouse) (0.1 mg vial)

Product Number: PDF-4504-s

Synonym(s): Crp4; Gly-Leu-Leu-Cys-Tyr-Cys-Arg-Lys-Gly-His-Cys-Lys-Arg-Gly-Glu-Arg-Val-Arg-Gly-Thr-Cys-Gly-Ile-Arg-Phe-Leu-Tyr-Cys-Cys-Pro-Arg-Arg

Disulfide Bonds: Bonds Between Cys4-Cys29, Cys6-Cys21, Cys11-Cys28

Application: Antimicrobial Peptide in Paneth Cells

Description: The most potent microbicidal of the mouse Paneth cell α-defensins and is degraded by MMP-7.

CAS Number: 610309-90-5

Molecular Weight (g/mol): 755.5

Storage Conditions: -20 °C

Reference(s): M.E. Selsted, S.I. Miller, A.H. Henschen, and A.J. Ouellette, J. Cell Biol., 118, 929 (1992). (Original) A.J. Ouellette, M.M. Hsieh, M.T. Nosek, D.F. Cano-Gauci, K.M. Huttner, R.N. Buick, and M.E. Selsted, Infect.Immun., 62, 5040 (1994). (Original) A.J. Ouellette, D. Darmoul, D. Tran, K.M. Huttner, J. Yuan, and M.E. Selsted, Infect.Immun., 67, 6643 (1999). (Chem. Synthesis & Pharmacol.) W. Jing, H.N. Hunter, H. Tanabe, A.J. Ouellette, and H.J. Vogel, Biochemistry, 43, 15759 (2004). (Solution Structure : NMR) K. Masuda, N. Sakai, K. Nakamura, S. Yoshioka, and T. Ayabe, J. Innate Immun., 3, 315 (2011). (Pharmacol.) E. Hayase, D. Hashimoto, K. Nakamura, C. Noizat, R. Ogasawara, S. Takahashi, H. Ohigashi, Y. Yokoi, R. Sugimoto, S. Matsuoka, T. Ara, E. Yokoyama, T. Yamakawa, K. Ebata, T. Kondo, R. Hiramine, T. Aizawa, Y.Ogura, T. Hayashi, H. Mori, K. Kurokawa, K. Tomizuka, T. Ayabe, and T. Teshima, J. Exp. Med., 214, 3507 (2017). (Pharmacol.)

Special Note(s): For research use ONLY. Not for use on humans.