Product Name: Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Edans

Product Number: SFQ-3764-PI

Synonym(s): DABCYL-TNF-alpha-EDANS (-4 to +6), human

One-Letter-Code: Dabcyl-LAQAVRSSSR-Edans

Application: TACE FRET Substrate I

Description: TNFa is presumably shed from cell membranes by TNFa-FW cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-α converting enzyme (TACE, ADAM17 endopeptidase) activity.;

Salt Form: Trifluoroacetate Salt

CAS Number: 396716-14-6

Molecular Weight (g/mol): 1573.81

Storage Conditions: -20 °C

Reference(s): K.M.Mohler et al., Nature, 370, 218 (1994) A.J.H.Gearing et al., Nature, 370, 555 (1994) B.F.Becker et al., Biol. Chem., 383, 1821 (2002) K.M. Mohler, et al., Nature, 370, 218 (1994). A.J.H. Gearing, et al., Nature, 370, 555 (1994). B.F. Becker, et al., Biol. Chem., 383, 1821 (2002).

Special Note(s): For research use ONLY. Not for use on humans.