Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu(Edans)-NH2 (1 mg vial)

Product Name: Dabcyl-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu(Edans)-NH2 (1 mg vial)

Product Number: SFS-3249-v

Synonym(s): Dabcyl-KTSAVLQSGFRKM(EEdans)-amide


Application: Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Main Protease (Mpro)

Description: This substrate contains the nsp4/nsp5 cleavage sequence, GVLQ↓SG19, and works as a generic peptide substrate for several coronavirus. The main protease (Mpro­), also called endopeptidase C30 or 3C-like proteinase (3CLpro), controls viral replication activities, and is a prime therapeutical target.; Contains SARS-CoV2 Replicase pp1ab (3235-3246). 1-2 week average availability Visit our COVID-19 Resource Page here.

Salt Form: Trifluoroacetate Salt

Molecular Weight (g/mol): 2080.4

Purity: ?95.0% (HPLC)

Storage Conditions: -20 °C

Reference(s): C.-J. Kuo, Y.-H. Chi, J.T.-A. Hsu, and P.-H. Liang, Biochem. Biophys. Res. Commun., 318, 862 (2004). (Substrate for SARS-CoV Main Protease) L. Zhang, D. Lin, X. Sun, U. Curth, C. Drosten, L. Sauerhering, S. Becker, K. Rox, and R. Hilgenfeld, Science, 368, 409 (2020). (Substrate for SARS-CoV-2 Main Protease) S. Jo et al., J Enzyme Inhib Med Chem, 35(1) 145 (2020).

Special Note(s): For research use ONLY. Not for use on humans.