Product Name: Melittin

Product Number: TOX-70001-PI

Synonym(s): H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2

One-Letter-Code: H-GIGAVLKVLTTGLPALISWIKRKRQQ-NH2

Application: Major Component of Bee Venom With Strong Hemolytic Activity; Seen to Increase Insulin Secretion Via Depolarization of Pancreatic beta-Cells

Description: A synthetic bee venom peptide

Source: Bee, Synthetic Product

Salt Form: Trifluoroacetate Salt

CAS Number: 20449-79-0

Molecular Weight (g/mol): 2846.53

Storage Conditions: -20 °C

Reference(s): T.C. Terwilliger and D. Eisenberg, J. Biol. Chem., 257, 6016 (1962). http://www.jbc.org/content/257/11/6016.full.pdf S. Hoissen, et al., J. Chem. (2017). Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus G. Yu, et al., Antimicrob Agents Chemotherapy, 60(3), 1717 (2016). Combination effects of antimicrobial peptides; doi: 10.1128/AAC02434-15. C.A. Rodriguez, et al., Chem Biol., 2, 71 (2014). Covalent modification of a ten-residue cationic antimicrobial peptide with levofloxacin. Y. Fukuyama, et al., Anal Chem.,; 84, 4237 (2012). Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis.

Special Note(s): For research use ONLY. Not for use on humans.